Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles

Abstract Transcranial magnetic stimulation (TMS) can be used to study excitability of corticospinal neurons in human motor cortex. It is currently not fully elucidated if corticospinal neurons in the hand vs. leg representation show the same or different regulation of their excitability by GABAAergi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Natalie Mrachacz-Kersting, Andrew James Thomas Stevenson, Ulf Ziemann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e0223d3da804c22b3b58e4509986d88
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e0223d3da804c22b3b58e4509986d88
record_format	dspace
spelling	oai:doaj.org-article:7e0223d3da804c22b3b58e4509986d882021-11-14T12:23:10ZShort-interval intracortical inhibition and facilitation targeting upper and lower limb muscles10.1038/s41598-021-01348-62045-2322https://doaj.org/article/7e0223d3da804c22b3b58e4509986d882021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01348-6https://doaj.org/toc/2045-2322Abstract Transcranial magnetic stimulation (TMS) can be used to study excitability of corticospinal neurons in human motor cortex. It is currently not fully elucidated if corticospinal neurons in the hand vs. leg representation show the same or different regulation of their excitability by GABAAergic and glutamatergic interneuronal circuitry. Using a paired-pulse TMS protocol we tested short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF) in 18 healthy participants. Motor evoked potentials were evoked in one hand (abductor digiti minimi) and one leg muscle (tibialis anterior), with systematic variation of the intensities of the first (S1) and second (S2) pulse between 60 and 140% resting motor threshold (RMT) in 10% steps, at two interstimulus intervals of 1.5 and 2.1 ms. For the hand and leg motor representations and for both interstimulus intervals, SICI occurred if the intensities of S1 < RMT and S2 > RMT, while SICF predominated if S1 = S2 ≤ RMT, or S1 > RMT and S2 < RMT. Findings confirm and extend previous evidence that the regulation of excitability of corticospinal neurons of the hand versus leg representation in human primary cortex through GABAAergic and glutamatergic interneuronal circuits is highly similar, and that corticospinal neurons of both representations are activated by TMS transsynaptically in largely identical ways.Natalie Mrachacz-KerstingAndrew James Thomas StevensonUlf ZiemannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalie Mrachacz-Kersting Andrew James Thomas Stevenson Ulf Ziemann Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
description	Abstract Transcranial magnetic stimulation (TMS) can be used to study excitability of corticospinal neurons in human motor cortex. It is currently not fully elucidated if corticospinal neurons in the hand vs. leg representation show the same or different regulation of their excitability by GABAAergic and glutamatergic interneuronal circuitry. Using a paired-pulse TMS protocol we tested short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF) in 18 healthy participants. Motor evoked potentials were evoked in one hand (abductor digiti minimi) and one leg muscle (tibialis anterior), with systematic variation of the intensities of the first (S1) and second (S2) pulse between 60 and 140% resting motor threshold (RMT) in 10% steps, at two interstimulus intervals of 1.5 and 2.1 ms. For the hand and leg motor representations and for both interstimulus intervals, SICI occurred if the intensities of S1 < RMT and S2 > RMT, while SICF predominated if S1 = S2 ≤ RMT, or S1 > RMT and S2 < RMT. Findings confirm and extend previous evidence that the regulation of excitability of corticospinal neurons of the hand versus leg representation in human primary cortex through GABAAergic and glutamatergic interneuronal circuits is highly similar, and that corticospinal neurons of both representations are activated by TMS transsynaptically in largely identical ways.
format	article
author	Natalie Mrachacz-Kersting Andrew James Thomas Stevenson Ulf Ziemann
author_facet	Natalie Mrachacz-Kersting Andrew James Thomas Stevenson Ulf Ziemann
author_sort	Natalie Mrachacz-Kersting
title	Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
title_short	Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
title_full	Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
title_fullStr	Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
title_full_unstemmed	Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
title_sort	short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7e0223d3da804c22b3b58e4509986d88
work_keys_str_mv	AT nataliemrachaczkersting shortintervalintracorticalinhibitionandfacilitationtargetingupperandlowerlimbmuscles AT andrewjamesthomasstevenson shortintervalintracorticalinhibitionandfacilitationtargetingupperandlowerlimbmuscles AT ulfziemann shortintervalintracorticalinhibitionandfacilitationtargetingupperandlowerlimbmuscles
_version_	1718429237491269632

Short-interval intracortical inhibition and facilitation targeting upper and lower limb muscles

Ejemplares similares