Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis

Abstract Development of advanced hepatic fibrosis in HFE Hemochromatosis (HH) is influenced by hepatic iron concentration (HIC) and age. In patients with HH, it is important to assess the likelihood of cirrhosis and thus the need for confirmatory liver biopsy. Therapeutic phlebotomy also provides an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Justin Chin, Lawrie W. Powell, Louise E. Ramm, Oyekoya T. Ayonrinde, Grant A. Ramm, John K. Olynyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e028c4a0cd04c32b5358cebea354c79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e028c4a0cd04c32b5358cebea354c79
record_format	dspace
spelling	oai:doaj.org-article:7e028c4a0cd04c32b5358cebea354c792021-12-02T13:35:02ZUtility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis10.1038/s41598-019-56732-02045-2322https://doaj.org/article/7e028c4a0cd04c32b5358cebea354c792019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56732-0https://doaj.org/toc/2045-2322Abstract Development of advanced hepatic fibrosis in HFE Hemochromatosis (HH) is influenced by hepatic iron concentration (HIC) and age. In patients with HH, it is important to assess the likelihood of cirrhosis and thus the need for confirmatory liver biopsy. Therapeutic phlebotomy also provides an estimate of mobilisable iron stores. We determined whether mobilisable iron stores may predict the presence of advanced fibrosis. Retrospective analysis of 137 male and 65 female HH subjects was undertaken. Biochemical, histological and phlebotomy data were available on all subjects. The mean values of HIC, HIC × [age], mobilisable iron, mobilisable iron × [age] and serum ferritin in the cohort were higher in the group with advanced fibrosis. HIC had an optimum sensitivity and specificity of 73% for the diagnosis of advanced liver fibrosis, with a cut-off HIC level of 200 µmol/g (AUROC 0.83, p < 0.0001). AUROC for HIC was greater in females (0.93) than males (0.79). Mobilisable iron had an optimum sensitivity and specificity both of 83% at a cut-off of 9.6 g for the prediction of advanced fibrosis in all subjects (AUROC 0.92, p < 0.0001). Mobilisable iron stores provide a simple, clinically useful indication of the risk of advanced fibrosis and should routinely be considered.Justin ChinLawrie W. PowellLouise E. RammOyekoya T. AyonrindeGrant A. RammJohn K. OlynykNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Justin Chin Lawrie W. Powell Louise E. Ramm Oyekoya T. Ayonrinde Grant A. Ramm John K. Olynyk Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
description	Abstract Development of advanced hepatic fibrosis in HFE Hemochromatosis (HH) is influenced by hepatic iron concentration (HIC) and age. In patients with HH, it is important to assess the likelihood of cirrhosis and thus the need for confirmatory liver biopsy. Therapeutic phlebotomy also provides an estimate of mobilisable iron stores. We determined whether mobilisable iron stores may predict the presence of advanced fibrosis. Retrospective analysis of 137 male and 65 female HH subjects was undertaken. Biochemical, histological and phlebotomy data were available on all subjects. The mean values of HIC, HIC × [age], mobilisable iron, mobilisable iron × [age] and serum ferritin in the cohort were higher in the group with advanced fibrosis. HIC had an optimum sensitivity and specificity of 73% for the diagnosis of advanced liver fibrosis, with a cut-off HIC level of 200 µmol/g (AUROC 0.83, p < 0.0001). AUROC for HIC was greater in females (0.93) than males (0.79). Mobilisable iron had an optimum sensitivity and specificity both of 83% at a cut-off of 9.6 g for the prediction of advanced fibrosis in all subjects (AUROC 0.92, p < 0.0001). Mobilisable iron stores provide a simple, clinically useful indication of the risk of advanced fibrosis and should routinely be considered.
format	article
author	Justin Chin Lawrie W. Powell Louise E. Ramm Oyekoya T. Ayonrinde Grant A. Ramm John K. Olynyk
author_facet	Justin Chin Lawrie W. Powell Louise E. Ramm Oyekoya T. Ayonrinde Grant A. Ramm John K. Olynyk
author_sort	Justin Chin
title	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
title_short	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
title_full	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
title_fullStr	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
title_full_unstemmed	Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis
title_sort	utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in hfe hemochromatosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7e028c4a0cd04c32b5358cebea354c79
work_keys_str_mv	AT justinchin utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis AT lawriewpowell utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis AT louiseeramm utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis AT oyekoyatayonrinde utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis AT grantaramm utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis AT johnkolynyk utilityofhepaticortotalbodyironburdenintheassessmentofadvancedhepaticfibrosisinhfehemochromatosis
_version_	1718392746133159936

Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis

Ejemplares similares