Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.

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Autores principales:	Sweta Iyer, Khatira Anwari, Amber E. Alsop, Wai Shan Yuen, David C. S. Huang, John Carroll, Nicholas A. Smith, Brian J. Smith, Grant Dewson, Ruth M. Kluck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e08a7aefe7a40b3835bb796864f5aae
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spelling	oai:doaj.org-article:7e08a7aefe7a40b3835bb796864f5aae2021-12-02T15:34:32ZIdentification of an activation site in Bak and mitochondrial Bax triggered by antibodies10.1038/ncomms117342041-1723https://doaj.org/article/7e08a7aefe7a40b3835bb796864f5aae2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11734https://doaj.org/toc/2041-1723During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.Sweta IyerKhatira AnwariAmber E. AlsopWai Shan YuenDavid C. S. HuangJohn CarrollNicholas A. SmithBrian J. SmithGrant DewsonRuth M. KluckNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
description	During apoptosis, Bak and Bax are activated by BH3-only proteins binding to a specific hydrophobic groove. Here, the authors show that antibodies can also activate Bak and mitochondrial Bax by binding to the α1-α2 loop, thus identifying a potential clinical target.
format	article
author	Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck
author_facet	Sweta Iyer Khatira Anwari Amber E. Alsop Wai Shan Yuen David C. S. Huang John Carroll Nicholas A. Smith Brian J. Smith Grant Dewson Ruth M. Kluck
author_sort	Sweta Iyer
title	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_short	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_full	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_fullStr	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_full_unstemmed	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
title_sort	identification of an activation site in bak and mitochondrial bax triggered by antibodies
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7e08a7aefe7a40b3835bb796864f5aae
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Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

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