Aging-associated oxidized albumin promotes cellular senescence and endothelial damage

Carlos Luna,1,* Matilde Alique,2,* Estefanía Navalmoral,2 Maria-Victoria Noci,3 Lourdes Bohorquez-Magro,2 Julia Carracedo,1 Rafael Ramírez2 1Nephrology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina S...

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Autores principales:	Luna C, Alique M, Navalmoral E, Noci MV, Bohorquez-Magro L, Carracedo J, Ramírez R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	elderly oxidative stress microparticles vascular damage. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7e0981ef63144853b972ea60eba5f624
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spelling	oai:doaj.org-article:7e0981ef63144853b972ea60eba5f6242021-12-02T06:08:46ZAging-associated oxidized albumin promotes cellular senescence and endothelial damage1178-1998https://doaj.org/article/7e0981ef63144853b972ea60eba5f6242016-02-01T00:00:00Zhttps://www.dovepress.com/aging-associated-oxidized-albumin-promotes-cellular-senescence-and-end-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Carlos Luna,1,* Matilde Alique,2,* Estefanía Navalmoral,2 Maria-Victoria Noci,3 Lourdes Bohorquez-Magro,2 Julia Carracedo,1 Rafael Ramírez2 1Nephrology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain; 2Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain; 3Anesthesia Unit, Reina sofía University Hospital, Córdoba, Spain*These authors contributed equally to this work Abstract: Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.Keywords: elderly, oxidative stress, microparticles, vascular damageLuna CAlique MNavalmoral ENoci MVBohorquez-Magro LCarracedo JRamírez RDove Medical Pressarticleelderlyoxidative stressmicroparticlesvascular damage.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 225-236 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	elderly oxidative stress microparticles vascular damage. Geriatrics RC952-954.6
spellingShingle	elderly oxidative stress microparticles vascular damage. Geriatrics RC952-954.6 Luna C Alique M Navalmoral E Noci MV Bohorquez-Magro L Carracedo J Ramírez R Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
description	Carlos Luna,1,* Matilde Alique,2,* Estefanía Navalmoral,2 Maria-Victoria Noci,3 Lourdes Bohorquez-Magro,2 Julia Carracedo,1 Rafael Ramírez2 1Nephrology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain; 2Department of Systems Biology, Physiology Unit, Universidad de Alcalá, Madrid, Spain; 3Anesthesia Unit, Reina sofía University Hospital, Córdoba, Spain*These authors contributed equally to this work Abstract: Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.Keywords: elderly, oxidative stress, microparticles, vascular damage
format	article
author	Luna C Alique M Navalmoral E Noci MV Bohorquez-Magro L Carracedo J Ramírez R
author_facet	Luna C Alique M Navalmoral E Noci MV Bohorquez-Magro L Carracedo J Ramírez R
author_sort	Luna C
title	Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
title_short	Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
title_full	Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
title_fullStr	Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
title_full_unstemmed	Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
title_sort	aging-associated oxidized albumin promotes cellular senescence and endothelial damage
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7e0981ef63144853b972ea60eba5f624
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Aging-associated oxidized albumin promotes cellular senescence and endothelial damage

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