Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.

<h4>Unlabelled</h4>Recent studies have revealed that a small non-coding RNA, microRNA (miRNA) down-regulates its mRNA targets. This effect is regarded as an important role in various biological processes. Many studies have been devoted to predicting miRNA-target interactions. These studi...

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Autores principales:	Wan J Hsieh, Feng-Mao Lin, Hsien-Da Huang, Hsiuying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e0d45a672834b689ed38efb7f6d001f
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spelling	oai:doaj.org-article:7e0d45a672834b689ed38efb7f6d001f2021-11-18T08:21:51ZInvestigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.1932-620310.1371/journal.pone.0095697https://doaj.org/article/7e0d45a672834b689ed38efb7f6d001f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24756070/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Recent studies have revealed that a small non-coding RNA, microRNA (miRNA) down-regulates its mRNA targets. This effect is regarded as an important role in various biological processes. Many studies have been devoted to predicting miRNA-target interactions. These studies indicate that the interactions may only be functional in some specific tissues, which depend on the characteristics of an miRNA. No systematic methods have been established in the literature to investigate the correlation between miRNA-target interactions and tissue specificity through microarray data. In this study, we propose a method to investigate miRNA-target interaction-supported tissues, which is based on experimentally validated miRNA-target interactions. The tissue specificity results by our method are in accordance with the experimental results in the literature.<h4>Availability and implementation</h4>Our analysis results are available at http://tsmti.mbc.nctu.edu.tw/ and http://www.stat.nctu.edu.tw/hwang/tsmti.html.Wan J HsiehFeng-Mao LinHsien-Da HuangHsiuying WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95697 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan J Hsieh Feng-Mao Lin Hsien-Da Huang Hsiuying Wang Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
description	<h4>Unlabelled</h4>Recent studies have revealed that a small non-coding RNA, microRNA (miRNA) down-regulates its mRNA targets. This effect is regarded as an important role in various biological processes. Many studies have been devoted to predicting miRNA-target interactions. These studies indicate that the interactions may only be functional in some specific tissues, which depend on the characteristics of an miRNA. No systematic methods have been established in the literature to investigate the correlation between miRNA-target interactions and tissue specificity through microarray data. In this study, we propose a method to investigate miRNA-target interaction-supported tissues, which is based on experimentally validated miRNA-target interactions. The tissue specificity results by our method are in accordance with the experimental results in the literature.<h4>Availability and implementation</h4>Our analysis results are available at http://tsmti.mbc.nctu.edu.tw/ and http://www.stat.nctu.edu.tw/hwang/tsmti.html.
format	article
author	Wan J Hsieh Feng-Mao Lin Hsien-Da Huang Hsiuying Wang
author_facet	Wan J Hsieh Feng-Mao Lin Hsien-Da Huang Hsiuying Wang
author_sort	Wan J Hsieh
title	Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
title_short	Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
title_full	Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
title_fullStr	Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
title_full_unstemmed	Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.
title_sort	investigating microrna-target interaction-supported tissues in human cancer tissues based on mirna and target gene expression profiling.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7e0d45a672834b689ed38efb7f6d001f
work_keys_str_mv	AT wanjhsieh investigatingmicrornatargetinteractionsupportedtissuesinhumancancertissuesbasedonmirnaandtargetgeneexpressionprofiling AT fengmaolin investigatingmicrornatargetinteractionsupportedtissuesinhumancancertissuesbasedonmirnaandtargetgeneexpressionprofiling AT hsiendahuang investigatingmicrornatargetinteractionsupportedtissuesinhumancancertissuesbasedonmirnaandtargetgeneexpressionprofiling AT hsiuyingwang investigatingmicrornatargetinteractionsupportedtissuesinhumancancertissuesbasedonmirnaandtargetgeneexpressionprofiling
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Investigating microRNA-target interaction-supported tissues in human cancer tissues based on miRNA and target gene expression profiling.

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