Natural Products and Synthetic Biology: Where We Are and Where We Need To Go

ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent cha...

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Autores principales:	Sylvia Kunakom, Alessandra S. Eustáquio
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	drug discovery bacterial genomes biosynthesis metabolites structure diversification Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7e0f0800bc6447f2aeacddf326f43dc4
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spelling	oai:doaj.org-article:7e0f0800bc6447f2aeacddf326f43dc42021-12-02T19:46:18ZNatural Products and Synthetic Biology: Where We Are and Where We Need To Go10.1128/mSystems.00113-192379-5077https://doaj.org/article/7e0f0800bc6447f2aeacddf326f43dc42019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00113-19https://doaj.org/toc/2379-5077ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.Sylvia KunakomAlessandra S. EustáquioAmerican Society for Microbiologyarticledrug discoverybacterial genomesbiosynthesismetabolitesstructure diversificationMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug discovery bacterial genomes biosynthesis metabolites structure diversification Microbiology QR1-502
spellingShingle	drug discovery bacterial genomes biosynthesis metabolites structure diversification Microbiology QR1-502 Sylvia Kunakom Alessandra S. Eustáquio Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
description	ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.
format	article
author	Sylvia Kunakom Alessandra S. Eustáquio
author_facet	Sylvia Kunakom Alessandra S. Eustáquio
author_sort	Sylvia Kunakom
title	Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
title_short	Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
title_full	Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
title_fullStr	Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
title_full_unstemmed	Natural Products and Synthetic Biology: Where We Are and Where We Need To Go
title_sort	natural products and synthetic biology: where we are and where we need to go
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/7e0f0800bc6447f2aeacddf326f43dc4
work_keys_str_mv	AT sylviakunakom naturalproductsandsyntheticbiologywhereweareandwhereweneedtogo AT alessandraseustaquio naturalproductsandsyntheticbiologywhereweareandwhereweneedtogo
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Natural Products and Synthetic Biology: Where We Are and Where We Need To Go

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