Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

Daily vinegar ingestion has been linked to improved glycemic control, but recent data suggest a separate unexplored role for vinegar in mental health. Utilizing a placebo-controlled, parallel arm study design, this 4-week trial examined the impact of daily vinegar ingestion on mood states and urinar...

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Autores principales:	Carol S. Johnston, Paniz Jasbi, Yan Jin, Shayna Bauer, Susanna Williams, Samantha N. Fessler, Haiwei Gu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	depression metabolomics vinegar Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7e109db4a4bf4a29adb5c51701821345
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spelling	oai:doaj.org-article:7e109db4a4bf4a29adb5c517018213452021-11-25T18:36:09ZDaily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial10.3390/nu131140202072-6643https://doaj.org/article/7e109db4a4bf4a29adb5c517018213452021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4020https://doaj.org/toc/2072-6643Daily vinegar ingestion has been linked to improved glycemic control, but recent data suggest a separate unexplored role for vinegar in mental health. Utilizing a placebo-controlled, parallel arm study design, this 4-week trial examined the impact of daily vinegar ingestion on mood states and urinary metabolites in healthy college students. Participants were randomized to the vinegar group (VIN: <i>n</i> = 14; 1.5 g acetic acid/day as liquid vinegar) or the control group (CON: <i>n</i> = 11; 0.015 g acetic acid/day as a pill) with no change to customary diet or physical activity. At baseline and at study week four, participants completed the Profile of Mood States (POMS) and the Center for Epidemiological Studies-Depression (CES-D) questionnaires and provided a first-morning urine sample for targeted metabolomics analyses. The change in both POMS depression scores and CES-D scores differed significantly between groups favoring improved affect in the VIN versus CON participants after four weeks. Metabolomics analyses pre and post-intervention suggested metabolite alterations associated with vinegar ingestion that are consistent for improved mood, including enzymatic dysfunction in the hexosamine pathway as well as significant increases in glycine, serine, and threonine metabolism. These data warrant continued investigation of vinegar as a possible agent to improve mood state.Carol S. JohnstonPaniz JasbiYan JinShayna BauerSusanna WilliamsSamantha N. FesslerHaiwei GuMDPI AGarticledepressionmetabolomicsvinegarNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4020, p 4020 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression metabolomics vinegar Nutrition. Foods and food supply TX341-641
spellingShingle	depression metabolomics vinegar Nutrition. Foods and food supply TX341-641 Carol S. Johnston Paniz Jasbi Yan Jin Shayna Bauer Susanna Williams Samantha N. Fessler Haiwei Gu Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
description	Daily vinegar ingestion has been linked to improved glycemic control, but recent data suggest a separate unexplored role for vinegar in mental health. Utilizing a placebo-controlled, parallel arm study design, this 4-week trial examined the impact of daily vinegar ingestion on mood states and urinary metabolites in healthy college students. Participants were randomized to the vinegar group (VIN: <i>n</i> = 14; 1.5 g acetic acid/day as liquid vinegar) or the control group (CON: <i>n</i> = 11; 0.015 g acetic acid/day as a pill) with no change to customary diet or physical activity. At baseline and at study week four, participants completed the Profile of Mood States (POMS) and the Center for Epidemiological Studies-Depression (CES-D) questionnaires and provided a first-morning urine sample for targeted metabolomics analyses. The change in both POMS depression scores and CES-D scores differed significantly between groups favoring improved affect in the VIN versus CON participants after four weeks. Metabolomics analyses pre and post-intervention suggested metabolite alterations associated with vinegar ingestion that are consistent for improved mood, including enzymatic dysfunction in the hexosamine pathway as well as significant increases in glycine, serine, and threonine metabolism. These data warrant continued investigation of vinegar as a possible agent to improve mood state.
format	article
author	Carol S. Johnston Paniz Jasbi Yan Jin Shayna Bauer Susanna Williams Samantha N. Fessler Haiwei Gu
author_facet	Carol S. Johnston Paniz Jasbi Yan Jin Shayna Bauer Susanna Williams Samantha N. Fessler Haiwei Gu
author_sort	Carol S. Johnston
title	Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
title_short	Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
title_full	Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
title_fullStr	Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
title_full_unstemmed	Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
title_sort	daily vinegar ingestion improves depression scores and alters the metabolome in healthy adults: a randomized controlled trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e109db4a4bf4a29adb5c51701821345
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Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial

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