The pathogenesis of mesothelioma is driven by a dysregulated translatome
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacol...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7e118ded480445418fbb52706c703037 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7e118ded480445418fbb52706c703037 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7e118ded480445418fbb52706c7030372021-12-02T18:50:56ZThe pathogenesis of mesothelioma is driven by a dysregulated translatome10.1038/s41467-021-25173-72041-1723https://doaj.org/article/7e118ded480445418fbb52706c7030372021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25173-7https://doaj.org/toc/2041-1723Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacological targets.Stefano GrossoAlberto MariniKatarina GyuraszovaJohan Vande VoordeAristeidis SfakianosGavin D. GarlandAngela Rubio TenorRyan MordueTanya ChernovaNobu MoroneMarco SerenoClaire P. SmithLeah OfficerPooyeh FarahmandClaire RooneyDavid SumptonMadhumita DasAna TeodósioCatherine FickenMaria Guerra MartinRuth V. SpriggsXiao-Ming SunMartin BushellOwen J. SansomDaniel MurphyMarion MacFarlaneJohn P. C. Le QuesneAnne E. WillisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Stefano Grosso Alberto Marini Katarina Gyuraszova Johan Vande Voorde Aristeidis Sfakianos Gavin D. Garland Angela Rubio Tenor Ryan Mordue Tanya Chernova Nobu Morone Marco Sereno Claire P. Smith Leah Officer Pooyeh Farahmand Claire Rooney David Sumpton Madhumita Das Ana Teodósio Catherine Ficken Maria Guerra Martin Ruth V. Spriggs Xiao-Ming Sun Martin Bushell Owen J. Sansom Daniel Murphy Marion MacFarlane John P. C. Le Quesne Anne E. Willis The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| description |
Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacological targets. |
| format |
article |
| author |
Stefano Grosso Alberto Marini Katarina Gyuraszova Johan Vande Voorde Aristeidis Sfakianos Gavin D. Garland Angela Rubio Tenor Ryan Mordue Tanya Chernova Nobu Morone Marco Sereno Claire P. Smith Leah Officer Pooyeh Farahmand Claire Rooney David Sumpton Madhumita Das Ana Teodósio Catherine Ficken Maria Guerra Martin Ruth V. Spriggs Xiao-Ming Sun Martin Bushell Owen J. Sansom Daniel Murphy Marion MacFarlane John P. C. Le Quesne Anne E. Willis |
| author_facet |
Stefano Grosso Alberto Marini Katarina Gyuraszova Johan Vande Voorde Aristeidis Sfakianos Gavin D. Garland Angela Rubio Tenor Ryan Mordue Tanya Chernova Nobu Morone Marco Sereno Claire P. Smith Leah Officer Pooyeh Farahmand Claire Rooney David Sumpton Madhumita Das Ana Teodósio Catherine Ficken Maria Guerra Martin Ruth V. Spriggs Xiao-Ming Sun Martin Bushell Owen J. Sansom Daniel Murphy Marion MacFarlane John P. C. Le Quesne Anne E. Willis |
| author_sort |
Stefano Grosso |
| title |
The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| title_short |
The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| title_full |
The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| title_fullStr |
The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| title_full_unstemmed |
The pathogenesis of mesothelioma is driven by a dysregulated translatome |
| title_sort |
pathogenesis of mesothelioma is driven by a dysregulated translatome |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7e118ded480445418fbb52706c703037 |
| work_keys_str_mv |
AT stefanogrosso thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT albertomarini thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT katarinagyuraszova thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT johanvandevoorde thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT aristeidissfakianos thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT gavindgarland thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT angelarubiotenor thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT ryanmordue thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT tanyachernova thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT nobumorone thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT marcosereno thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT clairepsmith thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT leahofficer thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT pooyehfarahmand thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT clairerooney thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT davidsumpton thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT madhumitadas thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT anateodosio thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT catherineficken thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT mariaguerramartin thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT ruthvspriggs thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT xiaomingsun thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT martinbushell thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT owenjsansom thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT danielmurphy thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT marionmacfarlane thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT johnpclequesne thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT anneewillis thepathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT stefanogrosso pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT albertomarini pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT katarinagyuraszova pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT johanvandevoorde pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT aristeidissfakianos pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT gavindgarland pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT angelarubiotenor pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT ryanmordue pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT tanyachernova pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT nobumorone pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT marcosereno pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT clairepsmith pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT leahofficer pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT pooyehfarahmand pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT clairerooney pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT davidsumpton pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT madhumitadas pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT anateodosio pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT catherineficken pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT mariaguerramartin pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT ruthvspriggs pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT xiaomingsun pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT martinbushell pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT owenjsansom pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT danielmurphy pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT marionmacfarlane pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT johnpclequesne pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome AT anneewillis pathogenesisofmesotheliomaisdrivenbyadysregulatedtranslatome |
| _version_ |
1718377455909076992 |