Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).

Short-term feed deprivation (or fasting) is a common occurrence in aquacultured fish species whether due to season, production strategies, or disease. In channel catfish (Ictalurus punctatus) fasting impacts susceptibility to several bacterial pathogens including Flavobacterium columnare, the causat...

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Autores principales:	Lisa Liu, Chao Li, Baofeng Su, Benjamin H Beck, Eric Peatman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e16721228524b6599a5a1dc21bd3a97
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spelling	oai:doaj.org-article:7e16721228524b6599a5a1dc21bd3a972021-11-18T08:56:51ZShort-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).1932-620310.1371/journal.pone.0074581https://doaj.org/article/7e16721228524b6599a5a1dc21bd3a972013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023952/?tool=EBIhttps://doaj.org/toc/1932-6203Short-term feed deprivation (or fasting) is a common occurrence in aquacultured fish species whether due to season, production strategies, or disease. In channel catfish (Ictalurus punctatus) fasting impacts susceptibility to several bacterial pathogens including Flavobacterium columnare, the causative agent of columnaris disease. As columnaris gains entry through the gills and skin of fish, we examined here changes in transcriptional regulation induced in these surface mucosal tissues due to short-term (7 day) fasting. RNA-seq expression analysis revealed a total of 1,545 genes perturbed by fasting. Fasting significantly altered expression of critical innate immune factors in a manner consistent with lower immune fitness as well as dysregulating key genes involved in energy metabolism and cell cycling/proliferation. Downregulation of innate immune actors such as iNOS2b, Lysozyme C, and peptidoglycan recognition protein 6 is predicted to impact the delicate recognition/tolerance balance for commensal and pathogenic bacteria on the skin and gill. The highlighted expression profiles reveal potential mechanistic similarities between gut and surface mucosa and underscore the complex interrelationships between nutrition, mucosal integrity, and immunity in teleost fish.Lisa LiuChao LiBaofeng SuBenjamin H BeckEric PeatmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74581 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa Liu Chao Li Baofeng Su Benjamin H Beck Eric Peatman Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
description	Short-term feed deprivation (or fasting) is a common occurrence in aquacultured fish species whether due to season, production strategies, or disease. In channel catfish (Ictalurus punctatus) fasting impacts susceptibility to several bacterial pathogens including Flavobacterium columnare, the causative agent of columnaris disease. As columnaris gains entry through the gills and skin of fish, we examined here changes in transcriptional regulation induced in these surface mucosal tissues due to short-term (7 day) fasting. RNA-seq expression analysis revealed a total of 1,545 genes perturbed by fasting. Fasting significantly altered expression of critical innate immune factors in a manner consistent with lower immune fitness as well as dysregulating key genes involved in energy metabolism and cell cycling/proliferation. Downregulation of innate immune actors such as iNOS2b, Lysozyme C, and peptidoglycan recognition protein 6 is predicted to impact the delicate recognition/tolerance balance for commensal and pathogenic bacteria on the skin and gill. The highlighted expression profiles reveal potential mechanistic similarities between gut and surface mucosa and underscore the complex interrelationships between nutrition, mucosal integrity, and immunity in teleost fish.
format	article
author	Lisa Liu Chao Li Baofeng Su Benjamin H Beck Eric Peatman
author_facet	Lisa Liu Chao Li Baofeng Su Benjamin H Beck Eric Peatman
author_sort	Lisa Liu
title	Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
title_short	Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
title_full	Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
title_fullStr	Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
title_full_unstemmed	Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).
title_sort	short-term feed deprivation alters immune status of surface mucosa in channel catfish (ictalurus punctatus).
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7e16721228524b6599a5a1dc21bd3a97
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Short-term feed deprivation alters immune status of surface mucosa in channel catfish (Ictalurus punctatus).

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