Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure

Low spot urinary creatinine concentration (SUCR) is a marker of muscle wasting and clinical outcome. The risk factors for low SUCR in heart failure (HF) remain poorly understood. We explored the risk factors for low SUCR related to poor outcomes. In 721 HF patients (age: 52.3 ± 11 years, female: 14%...

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Autores principales:	Jolanta Malinowska-Borowska, Aleksandra Kulik, Marta Buczkowska, Weronika Ostręga, Apolonia Stefaniak, Małgorzata Piecuch, Jagoda Garbicz, Jolanta Urszula Nowak, Mateusz Tajstra, Ewa Anita Jankowska, Mariusz Gąsior, Piotr Rozentryt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spot urinary creatinine concentration nutritional predictors non-nutritional predictors heart failure Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7e1a0876c7ce4a918ed39bfaea00ca04
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spelling	oai:doaj.org-article:7e1a0876c7ce4a918ed39bfaea00ca042021-11-25T18:35:53ZNutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure10.3390/nu131139942072-6643https://doaj.org/article/7e1a0876c7ce4a918ed39bfaea00ca042021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3994https://doaj.org/toc/2072-6643Low spot urinary creatinine concentration (SUCR) is a marker of muscle wasting and clinical outcome. The risk factors for low SUCR in heart failure (HF) remain poorly understood. We explored the risk factors for low SUCR related to poor outcomes. In 721 HF patients (age: 52.3 ± 11 years, female: 14%, NYHA: 2.7 ± 0.7) SUCR and Dexa body composition scans were performed. BMI prior HF-onset, weight loss, and appendicular muscle mass were obtained. Each patient was classified as malnutrition or normal by GLIM criteria and three other biochemical indices (CONUT, PNI, and GRNI). Sarcopenia index (SI) as creatinine to cystatin C ratio was also calculated. Within 1 year, 80 (11.1%) patients died. In ROC curve we identified a SUCR value of 0.628 g/L as optimally discriminating surviving from dead. In low SUCR group more advanced HF, higher weight loss and catabolic components of weight trajectory (CCWT), more frequent under-nutrition by GLIM, and lower SI were observed. In multivariate analysis the independent predictors of low SUCR were SI, CCWT, and GNRI score. In conclusion: the risk of low SUCR was associated with a worse outcome. Low SUCR was associated with greater catabolism and sarcopenia but not with biochemical indices of malnutrition.Jolanta Malinowska-BorowskaAleksandra KulikMarta BuczkowskaWeronika OstręgaApolonia StefaniakMałgorzata PiecuchJagoda GarbiczJolanta Urszula NowakMateusz TajstraEwa Anita JankowskaMariusz GąsiorPiotr RozentrytMDPI AGarticlespot urinary creatinine concentrationnutritional predictorsnon-nutritional predictorsheart failureNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3994, p 3994 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spot urinary creatinine concentration nutritional predictors non-nutritional predictors heart failure Nutrition. Foods and food supply TX341-641
spellingShingle	spot urinary creatinine concentration nutritional predictors non-nutritional predictors heart failure Nutrition. Foods and food supply TX341-641 Jolanta Malinowska-Borowska Aleksandra Kulik Marta Buczkowska Weronika Ostręga Apolonia Stefaniak Małgorzata Piecuch Jagoda Garbicz Jolanta Urszula Nowak Mateusz Tajstra Ewa Anita Jankowska Mariusz Gąsior Piotr Rozentryt Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
description	Low spot urinary creatinine concentration (SUCR) is a marker of muscle wasting and clinical outcome. The risk factors for low SUCR in heart failure (HF) remain poorly understood. We explored the risk factors for low SUCR related to poor outcomes. In 721 HF patients (age: 52.3 ± 11 years, female: 14%, NYHA: 2.7 ± 0.7) SUCR and Dexa body composition scans were performed. BMI prior HF-onset, weight loss, and appendicular muscle mass were obtained. Each patient was classified as malnutrition or normal by GLIM criteria and three other biochemical indices (CONUT, PNI, and GRNI). Sarcopenia index (SI) as creatinine to cystatin C ratio was also calculated. Within 1 year, 80 (11.1%) patients died. In ROC curve we identified a SUCR value of 0.628 g/L as optimally discriminating surviving from dead. In low SUCR group more advanced HF, higher weight loss and catabolic components of weight trajectory (CCWT), more frequent under-nutrition by GLIM, and lower SI were observed. In multivariate analysis the independent predictors of low SUCR were SI, CCWT, and GNRI score. In conclusion: the risk of low SUCR was associated with a worse outcome. Low SUCR was associated with greater catabolism and sarcopenia but not with biochemical indices of malnutrition.
format	article
author	Jolanta Malinowska-Borowska Aleksandra Kulik Marta Buczkowska Weronika Ostręga Apolonia Stefaniak Małgorzata Piecuch Jagoda Garbicz Jolanta Urszula Nowak Mateusz Tajstra Ewa Anita Jankowska Mariusz Gąsior Piotr Rozentryt
author_facet	Jolanta Malinowska-Borowska Aleksandra Kulik Marta Buczkowska Weronika Ostręga Apolonia Stefaniak Małgorzata Piecuch Jagoda Garbicz Jolanta Urszula Nowak Mateusz Tajstra Ewa Anita Jankowska Mariusz Gąsior Piotr Rozentryt
author_sort	Jolanta Malinowska-Borowska
title	Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
title_short	Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
title_full	Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
title_fullStr	Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
title_full_unstemmed	Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure
title_sort	nutritional and non-nutritional predictors of low spot urinary creatinine concentration in patients with heart failure
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e1a0876c7ce4a918ed39bfaea00ca04
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Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure

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