Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study

Zhonglun Mai,1,&ast; Bin Feng,2,&ast; Qianwen He,3 Qixiao Feng1 1Department of Thoracic Oncology, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510315, People’s Republic of China; 2Department of Oncology, The F...

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Autores principales:	Mai Z, Feng B, He Q, Feng Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	medical thoracoscopy thermal ablation argon plasma coagulation metastatic pleural tumor malignant pleural effusion non-small-cell lung cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7e1b2654d508433b9e81e3e96ad93b79
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spelling	oai:doaj.org-article:7e1b2654d508433b9e81e3e96ad93b792021-12-05T18:27:45ZMedical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study1178-7074https://doaj.org/article/7e1b2654d508433b9e81e3e96ad93b792021-12-01T00:00:00Zhttps://www.dovepress.com/medical-thoracoscopic-thermal-ablation-therapy-for-metastatic-pleural--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Zhonglun Mai,1,&ast; Bin Feng,2,&ast; Qianwen He,3 Qixiao Feng1 1Department of Thoracic Oncology, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510315, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510630, People’s Republic of China; 3Department of Geriatrics, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510315, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qixiao Feng Tel +86 18520088212Email cxhfqx@163.comZhonglun Mai Email maizhonglun@126.comPurpose: Malignant pleural effusion (MPE) is an intractable condition. The current mainstream therapies for MPE, ie, indwelling pleural catheter and pleurodesis, have some drawbacks. In this retrospective study, we explored the efficacy and safety of medical thoracoscopic thermal ablation (argon plasma coagulation, APC) therapy for metastatic pleural tumors with MPE.Patients and Methods: A total of 176 patients were enrolled and divided into catheter pleural drainage (CPD) group (n = 77), non-ablation group (n = 46), and thermal ablation group (n = 53). Propensity score matching (PSM) was used for between-group comparisons to minimize bias. The primary endpoints were pleural effusion objective response rate (ORR) and time to progression (TTP); secondary endpoints included overall survival (OS), chest-tube duration, and safety.Results: Thermal ablation group and non-ablation group showed significantly higher ORR and shorter chest-tube duration versus the CPD group (ORR: thermal ablation, 88.2% vs 66.7%, P = 0.004; non-ablation, 88.4% vs 64.4%, P = 0.042; chest-tube duration: thermal ablation, 4.90 vs 7.24 days, P < 0.001; non-ablation, 5.73 vs 7.33 days, P = 0.010). Thermal ablation group exhibited longer TTP than the CPD group (median, 13.7 vs 7.3 months, P = 0.001) and the non-ablation group (median, 13.6 vs 10.3 months, P = 0.037). OS in the thermal ablation group was numerically longer than that in the CPD group with marginally significant difference (P = 0.055). There was no significant difference in the frequency of adverse events or changes in vital signs between thermal ablation and non-ablation groups.Conclusion: Medical thoracoscopic thermal ablation (APC technique) therapy was effective and safe in the treatment of metastatic pleural tumors with MPE for improving ORR and TTP.Keywords: medical thoracoscopy, thermal ablation, argon plasma coagulation, metastatic pleural tumor, malignant pleural effusion, non-small-cell lung cancerMai ZFeng BHe QFeng QDove Medical Pressarticlemedical thoracoscopythermal ablationargon plasma coagulationmetastatic pleural tumormalignant pleural effusionnon-small-cell lung cancerMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9349-9360 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	medical thoracoscopy thermal ablation argon plasma coagulation metastatic pleural tumor malignant pleural effusion non-small-cell lung cancer Medicine (General) R5-920
spellingShingle	medical thoracoscopy thermal ablation argon plasma coagulation metastatic pleural tumor malignant pleural effusion non-small-cell lung cancer Medicine (General) R5-920 Mai Z Feng B He Q Feng Q Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
description	Zhonglun Mai,1,&ast; Bin Feng,2,&ast; Qianwen He,3 Qixiao Feng1 1Department of Thoracic Oncology, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510315, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510630, People’s Republic of China; 3Department of Geriatrics, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, 510315, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qixiao Feng Tel +86 18520088212Email cxhfqx@163.comZhonglun Mai Email maizhonglun@126.comPurpose: Malignant pleural effusion (MPE) is an intractable condition. The current mainstream therapies for MPE, ie, indwelling pleural catheter and pleurodesis, have some drawbacks. In this retrospective study, we explored the efficacy and safety of medical thoracoscopic thermal ablation (argon plasma coagulation, APC) therapy for metastatic pleural tumors with MPE.Patients and Methods: A total of 176 patients were enrolled and divided into catheter pleural drainage (CPD) group (n = 77), non-ablation group (n = 46), and thermal ablation group (n = 53). Propensity score matching (PSM) was used for between-group comparisons to minimize bias. The primary endpoints were pleural effusion objective response rate (ORR) and time to progression (TTP); secondary endpoints included overall survival (OS), chest-tube duration, and safety.Results: Thermal ablation group and non-ablation group showed significantly higher ORR and shorter chest-tube duration versus the CPD group (ORR: thermal ablation, 88.2% vs 66.7%, P = 0.004; non-ablation, 88.4% vs 64.4%, P = 0.042; chest-tube duration: thermal ablation, 4.90 vs 7.24 days, P < 0.001; non-ablation, 5.73 vs 7.33 days, P = 0.010). Thermal ablation group exhibited longer TTP than the CPD group (median, 13.7 vs 7.3 months, P = 0.001) and the non-ablation group (median, 13.6 vs 10.3 months, P = 0.037). OS in the thermal ablation group was numerically longer than that in the CPD group with marginally significant difference (P = 0.055). There was no significant difference in the frequency of adverse events or changes in vital signs between thermal ablation and non-ablation groups.Conclusion: Medical thoracoscopic thermal ablation (APC technique) therapy was effective and safe in the treatment of metastatic pleural tumors with MPE for improving ORR and TTP.Keywords: medical thoracoscopy, thermal ablation, argon plasma coagulation, metastatic pleural tumor, malignant pleural effusion, non-small-cell lung cancer
format	article
author	Mai Z Feng B He Q Feng Q
author_facet	Mai Z Feng B He Q Feng Q
author_sort	Mai Z
title	Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
title_short	Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
title_full	Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
title_fullStr	Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
title_full_unstemmed	Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study
title_sort	medical thoracoscopic thermal ablation therapy for metastatic pleural tumors with malignant effusion: an exploratory retrospective study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7e1b2654d508433b9e81e3e96ad93b79
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Medical Thoracoscopic Thermal Ablation Therapy for Metastatic Pleural Tumors with Malignant Effusion: An Exploratory Retrospective Study

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