Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Cionabinds gut bacteria and chitin-rich gut mucosa, influences biofilm formation and...

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Autores principales:	Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis, Gary W. Litman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e1d848d9d37487ca67bad82f4ee9607
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spelling	oai:doaj.org-article:7e1d848d9d37487ca67bad82f4ee96072021-12-02T16:49:40ZGut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria10.1038/ncomms106172041-1723https://doaj.org/article/7e1d848d9d37487ca67bad82f4ee96072016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10617https://doaj.org/toc/2041-1723Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Cionabinds gut bacteria and chitin-rich gut mucosa, influences biofilm formation and likely plays a role in gut homeostasis.Larry J. DishawBrittany LeighJohn P. CannonAssunta LibertiM. Gail MuellerDiana P. SkapuraCharlotte R. KarrerMaria R. PintoRosaria De SantisGary W. LitmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Larry J. Dishaw Brittany Leigh John P. Cannon Assunta Liberti M. Gail Mueller Diana P. Skapura Charlotte R. Karrer Maria R. Pinto Rosaria De Santis Gary W. Litman Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
description	Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Cionabinds gut bacteria and chitin-rich gut mucosa, influences biofilm formation and likely plays a role in gut homeostasis.
format	article
author	Larry J. Dishaw Brittany Leigh John P. Cannon Assunta Liberti M. Gail Mueller Diana P. Skapura Charlotte R. Karrer Maria R. Pinto Rosaria De Santis Gary W. Litman
author_facet	Larry J. Dishaw Brittany Leigh John P. Cannon Assunta Liberti M. Gail Mueller Diana P. Skapura Charlotte R. Karrer Maria R. Pinto Rosaria De Santis Gary W. Litman
author_sort	Larry J. Dishaw
title	Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
title_short	Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
title_full	Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
title_fullStr	Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
title_full_unstemmed	Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
title_sort	gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7e1d848d9d37487ca67bad82f4ee9607
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Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

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