Sertoli cell ablation and replacement of the spermatogonial niche in mouse

Sertoli cells and other somatic cells of the testis comprise the germ cell niche and are critical to regulate spermatogenesis. Here the authors present a method in which Sertoli cells are selectively targeted for ablation by the compound benzalkonium chloride (BC) in mice, and the spermatogenic nich...

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Autores principales:	Tetsuhiro Yokonishi, Jennifer McKey, Shintaro Ide, Blanche Capel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e1fa12214124896b8ec0c7085d0d0b3
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spelling	oai:doaj.org-article:7e1fa12214124896b8ec0c7085d0d0b32021-12-02T15:34:14ZSertoli cell ablation and replacement of the spermatogonial niche in mouse10.1038/s41467-019-13879-82041-1723https://doaj.org/article/7e1fa12214124896b8ec0c7085d0d0b32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13879-8https://doaj.org/toc/2041-1723Sertoli cells and other somatic cells of the testis comprise the germ cell niche and are critical to regulate spermatogenesis. Here the authors present a method in which Sertoli cells are selectively targeted for ablation by the compound benzalkonium chloride (BC) in mice, and the spermatogenic niche is subsequently repopulated in regions that have been affected by BC treatment.Tetsuhiro YokonishiJennifer McKeyShintaro IdeBlanche CapelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tetsuhiro Yokonishi Jennifer McKey Shintaro Ide Blanche Capel Sertoli cell ablation and replacement of the spermatogonial niche in mouse
description	Sertoli cells and other somatic cells of the testis comprise the germ cell niche and are critical to regulate spermatogenesis. Here the authors present a method in which Sertoli cells are selectively targeted for ablation by the compound benzalkonium chloride (BC) in mice, and the spermatogenic niche is subsequently repopulated in regions that have been affected by BC treatment.
format	article
author	Tetsuhiro Yokonishi Jennifer McKey Shintaro Ide Blanche Capel
author_facet	Tetsuhiro Yokonishi Jennifer McKey Shintaro Ide Blanche Capel
author_sort	Tetsuhiro Yokonishi
title	Sertoli cell ablation and replacement of the spermatogonial niche in mouse
title_short	Sertoli cell ablation and replacement of the spermatogonial niche in mouse
title_full	Sertoli cell ablation and replacement of the spermatogonial niche in mouse
title_fullStr	Sertoli cell ablation and replacement of the spermatogonial niche in mouse
title_full_unstemmed	Sertoli cell ablation and replacement of the spermatogonial niche in mouse
title_sort	sertoli cell ablation and replacement of the spermatogonial niche in mouse
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7e1fa12214124896b8ec0c7085d0d0b3
work_keys_str_mv	AT tetsuhiroyokonishi sertolicellablationandreplacementofthespermatogonialnicheinmouse AT jennifermckey sertolicellablationandreplacementofthespermatogonialnicheinmouse AT shintaroide sertolicellablationandreplacementofthespermatogonialnicheinmouse AT blanchecapel sertolicellablationandreplacementofthespermatogonialnicheinmouse
_version_	1718386909984587776

Sertoli cell ablation and replacement of the spermatogonial niche in mouse

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