Contribution of different etiology factors in fading pregnancy occurrence

Aim. Evaluate the contribution of non-genetic and genetic factors to the occurrence of fading pregnancy at the terms of less / more than 12 weeks of gestation.  Material and Methods. The clinical examinations, analysis of genealogical information and laboratory studies, in particular, cytogenetic...

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Autores principales: M. Lozynska, N. Prokopchuk, M. Mikula, Ja. Korinets, O. Oleksiuk
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Lenguaje:EN
UK
Publicado: Danylo Halytsky Lviv National Medical University 2018
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Acceso en línea:https://doaj.org/article/7e2001d9e11a4cd6bc6d001023ad2dfd
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spelling oai:doaj.org-article:7e2001d9e11a4cd6bc6d001023ad2dfd2021-11-10T19:49:52ZContribution of different etiology factors in fading pregnancy occurrence1029-42442415-330310.25040/aml2018.04.018https://doaj.org/article/7e2001d9e11a4cd6bc6d001023ad2dfd2018-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/83https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. Evaluate the contribution of non-genetic and genetic factors to the occurrence of fading pregnancy at the terms of less / more than 12 weeks of gestation.  Material and Methods. The clinical examinations, analysis of genealogical information and laboratory studies, in particular, cytogenetic analysis in 43 couples (86 patients) with history of pregnancy fading were carried out. The spectrum of chromosomal abnormalities in the materials of fading pregnancies was determined using the analysis of medical documentation.  Results and Discussion. Fading pregnancy was detected in 79.1% of married couples at the terms of pregnancy <12 weeks. The most common cause of fading pregnancy of not of genetic nature was infectious diseases (TORCH-infection) that found in 44.2% of patients and occupational hazards risk factors was detected in 27.9% persons. Pathology of the genital area was found in 16.3% of patients. In 11.8% of married couples with stopped pregnancy at the term of less than 12 weeks an elevated level of lupus anticoagulant was detected. Eleven point eight percents of I degree relatives of the patients had a history of miscarriage or fading of pregnancies, or infertility more than 10 years. Chromosomal abnormalities were detected in 4.7% of married couples. In 9.5% of married couples was confirmed pericentric inversion of chromosome 9. In the material of fading pregnancies, the predominance of additional copies of autosomes and monosomal chromosome X among chromosomal abnormalities were registered. Chromosomal pathology was detected on a term of pregnancy less than 12 weeks in 32,4% of embryos and on a term of pregnancy more than 12 weeks -  in 33,3% of fetus.  Conclusion. Investigation of probable risk factors of non-genetic and genetic nature in married couples with fading pregnancy allows predicting possible repeated reproductive losses.M. LozynskaN. ProkopchukM. MikulaJa. KorinetsO. OleksiukDanylo Halytsky Lviv National Medical Universityarticlechromosomal anomalies, fading pregnancy, concomitant diseases, the risk factors of fading pregnancyMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 24, Iss 4, Pp 18-23 (2018)
institution DOAJ
collection DOAJ
language EN
UK
topic chromosomal anomalies, fading pregnancy, concomitant diseases, the risk factors of fading pregnancy
Medicine (General)
R5-920
spellingShingle chromosomal anomalies, fading pregnancy, concomitant diseases, the risk factors of fading pregnancy
Medicine (General)
R5-920
M. Lozynska
N. Prokopchuk
M. Mikula
Ja. Korinets
O. Oleksiuk
Contribution of different etiology factors in fading pregnancy occurrence
description Aim. Evaluate the contribution of non-genetic and genetic factors to the occurrence of fading pregnancy at the terms of less / more than 12 weeks of gestation.  Material and Methods. The clinical examinations, analysis of genealogical information and laboratory studies, in particular, cytogenetic analysis in 43 couples (86 patients) with history of pregnancy fading were carried out. The spectrum of chromosomal abnormalities in the materials of fading pregnancies was determined using the analysis of medical documentation.  Results and Discussion. Fading pregnancy was detected in 79.1% of married couples at the terms of pregnancy <12 weeks. The most common cause of fading pregnancy of not of genetic nature was infectious diseases (TORCH-infection) that found in 44.2% of patients and occupational hazards risk factors was detected in 27.9% persons. Pathology of the genital area was found in 16.3% of patients. In 11.8% of married couples with stopped pregnancy at the term of less than 12 weeks an elevated level of lupus anticoagulant was detected. Eleven point eight percents of I degree relatives of the patients had a history of miscarriage or fading of pregnancies, or infertility more than 10 years. Chromosomal abnormalities were detected in 4.7% of married couples. In 9.5% of married couples was confirmed pericentric inversion of chromosome 9. In the material of fading pregnancies, the predominance of additional copies of autosomes and monosomal chromosome X among chromosomal abnormalities were registered. Chromosomal pathology was detected on a term of pregnancy less than 12 weeks in 32,4% of embryos and on a term of pregnancy more than 12 weeks -  in 33,3% of fetus.  Conclusion. Investigation of probable risk factors of non-genetic and genetic nature in married couples with fading pregnancy allows predicting possible repeated reproductive losses.
format article
author M. Lozynska
N. Prokopchuk
M. Mikula
Ja. Korinets
O. Oleksiuk
author_facet M. Lozynska
N. Prokopchuk
M. Mikula
Ja. Korinets
O. Oleksiuk
author_sort M. Lozynska
title Contribution of different etiology factors in fading pregnancy occurrence
title_short Contribution of different etiology factors in fading pregnancy occurrence
title_full Contribution of different etiology factors in fading pregnancy occurrence
title_fullStr Contribution of different etiology factors in fading pregnancy occurrence
title_full_unstemmed Contribution of different etiology factors in fading pregnancy occurrence
title_sort contribution of different etiology factors in fading pregnancy occurrence
publisher Danylo Halytsky Lviv National Medical University
publishDate 2018
url https://doaj.org/article/7e2001d9e11a4cd6bc6d001023ad2dfd
work_keys_str_mv AT mlozynska contributionofdifferentetiologyfactorsinfadingpregnancyoccurrence
AT nprokopchuk contributionofdifferentetiologyfactorsinfadingpregnancyoccurrence
AT mmikula contributionofdifferentetiologyfactorsinfadingpregnancyoccurrence
AT jakorinets contributionofdifferentetiologyfactorsinfadingpregnancyoccurrence
AT ooleksiuk contributionofdifferentetiologyfactorsinfadingpregnancyoccurrence
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