The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals

Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR) and rexinoid nuclear receptors (RXR), which a...

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Autores principales:	Macejova Dana, Toporova L., Brtko J.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	retinoic acid retinoic acid receptors retinoid x receptors reproduction organotin compounds endocrine disruptor Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/7e21c2371940453bbf0870e97980c88a
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spelling	oai:doaj.org-article:7e21c2371940453bbf0870e97980c88a2021-12-02T19:10:34ZThe role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals1336-032910.1515/enr-2016-0018https://doaj.org/article/7e21c2371940453bbf0870e97980c88a2016-07-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0018https://doaj.org/toc/1336-0329Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR) and rexinoid nuclear receptors (RXR), which are considered to be a ligand-activated, DNA-binding, trans-acting, and transcription-modulating proteins, involved in a general molecular mechanism responsible for the transcriptional responses in target genes. Organotin compounds are typical environmental contaminants and suspected endocrine disrupting substances. They may affect processes of reproductive system in mammals, predominantly via nuclear receptor signaling pathways. Triorganotins, such as tributyltin chloride (TBTCl) and triphenyltin chloride (TPTCl), are capable to bind to RXR molecules, and thus represent potent agonists of RXR subtypes of nuclear receptors not sharing any structural characteristics with endogenous ligands of nuclear receptors. Th is article summarizes selected effects of biologically active retinoids and rexinoids on both male and female reproduction and also deals with the effects of organotin compounds evoking endocrine disrupting actions in reproduction.Macejova DanaToporova L.Brtko J.Sciendoarticleretinoic acidretinoic acid receptorsretinoid x receptorsreproductionorganotin compoundsendocrine disruptorDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 3, Pp 154-164 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinoic acid retinoic acid receptors retinoid x receptors reproduction organotin compounds endocrine disruptor Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	retinoic acid retinoic acid receptors retinoid x receptors reproduction organotin compounds endocrine disruptor Diseases of the endocrine glands. Clinical endocrinology RC648-665 Macejova Dana Toporova L. Brtko J. The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
description	Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR) and rexinoid nuclear receptors (RXR), which are considered to be a ligand-activated, DNA-binding, trans-acting, and transcription-modulating proteins, involved in a general molecular mechanism responsible for the transcriptional responses in target genes. Organotin compounds are typical environmental contaminants and suspected endocrine disrupting substances. They may affect processes of reproductive system in mammals, predominantly via nuclear receptor signaling pathways. Triorganotins, such as tributyltin chloride (TBTCl) and triphenyltin chloride (TPTCl), are capable to bind to RXR molecules, and thus represent potent agonists of RXR subtypes of nuclear receptors not sharing any structural characteristics with endogenous ligands of nuclear receptors. Th is article summarizes selected effects of biologically active retinoids and rexinoids on both male and female reproduction and also deals with the effects of organotin compounds evoking endocrine disrupting actions in reproduction.
format	article
author	Macejova Dana Toporova L. Brtko J.
author_facet	Macejova Dana Toporova L. Brtko J.
author_sort	Macejova Dana
title	The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
title_short	The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
title_full	The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
title_fullStr	The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
title_full_unstemmed	The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
title_sort	role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/7e21c2371940453bbf0870e97980c88a
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The role of retinoic acid receptors and their cognate ligands in reproduction in a context of triorganotin based endocrine disrupting chemicals

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