Chronic liver disease not a significant comorbid condition for COVID-19

Abstract To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes w...

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Autores principales:	Jiahao Lin, Bingting Bao, Nigar Anjuman Khurram, Kasey Halsey, Ji Whae Choi, Lesan Wang, Thi My Linh Tran, Wei-Hua Liao, Michael D. Feldman, Paul J. Zhang, Jing Wu, Harrison X. Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e22fe39208741a2aba86e8d6b795ae7
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spelling	oai:doaj.org-article:7e22fe39208741a2aba86e8d6b795ae72021-12-02T17:51:21ZChronic liver disease not a significant comorbid condition for COVID-1910.1038/s41598-021-91238-82045-2322https://doaj.org/article/7e22fe39208741a2aba86e8d6b795ae72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91238-8https://doaj.org/toc/2045-2322Abstract To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p = 0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p = 0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.Jiahao LinBingting BaoNigar Anjuman KhurramKasey HalseyJi Whae ChoiLesan WangThi My Linh TranWei-Hua LiaoMichael D. FeldmanPaul J. ZhangJing WuHarrison X. BaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiahao Lin Bingting Bao Nigar Anjuman Khurram Kasey Halsey Ji Whae Choi Lesan Wang Thi My Linh Tran Wei-Hua Liao Michael D. Feldman Paul J. Zhang Jing Wu Harrison X. Bai Chronic liver disease not a significant comorbid condition for COVID-19
description	Abstract To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April 23, 2020 were retrospectively identified. Clinical characteristics and outcomes were compared between patients with and without CLD. Postmortem examination of liver in 8 critically ill COVID-19 patients was performed. There was no significant difference in the incidence of CLD between critical and non-critical groups (4.1% vs 2.9%, p = 0.259), or COVID-19 related liver injury between patients with and without CLD (65.7% vs 49.7%, p = 0.065). Postmortem examination of liver demonstrated mild liver injury associated central vein outflow obstruction and minimal to moderate portal lymphocytic infiltrate without evidence of CLD. Patients with CLD were not associated with a higher risk of liver injury or critical/fatal outcomes. CLD was not a significant comorbid condition for COVID-19.
format	article
author	Jiahao Lin Bingting Bao Nigar Anjuman Khurram Kasey Halsey Ji Whae Choi Lesan Wang Thi My Linh Tran Wei-Hua Liao Michael D. Feldman Paul J. Zhang Jing Wu Harrison X. Bai
author_facet	Jiahao Lin Bingting Bao Nigar Anjuman Khurram Kasey Halsey Ji Whae Choi Lesan Wang Thi My Linh Tran Wei-Hua Liao Michael D. Feldman Paul J. Zhang Jing Wu Harrison X. Bai
author_sort	Jiahao Lin
title	Chronic liver disease not a significant comorbid condition for COVID-19
title_short	Chronic liver disease not a significant comorbid condition for COVID-19
title_full	Chronic liver disease not a significant comorbid condition for COVID-19
title_fullStr	Chronic liver disease not a significant comorbid condition for COVID-19
title_full_unstemmed	Chronic liver disease not a significant comorbid condition for COVID-19
title_sort	chronic liver disease not a significant comorbid condition for covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7e22fe39208741a2aba86e8d6b795ae7
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Chronic liver disease not a significant comorbid condition for COVID-19

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