Single-cell analysis based dissection of clonality in myelofibrosis
Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.
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Nature Portfolio
2020
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oai:doaj.org-article:7e23582169274e9ab60ff7109190fa372021-12-02T17:32:28ZSingle-cell analysis based dissection of clonality in myelofibrosis10.1038/s41467-019-13892-x2041-1723https://doaj.org/article/7e23582169274e9ab60ff7109190fa372020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13892-xhttps://doaj.org/toc/2041-1723Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.Elena MylonasKenichi YoshidaMareike FrickKaja HoyerFriederike ChristenJaspal KaedaMatthias ObenausDaniel NoerenbergCornelius HennchWilly ChanYotaro OchiYuichi ShiraishiYusuke ShiozawaThorsten ZenzChristopher C. OakesBirgit SawitzkiMichaela SchwarzLars BullingerPhilipp le CoutreMatthew J. J. Rose-ZerilliSeishi OgawaFrederik DammNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Elena Mylonas Kenichi Yoshida Mareike Frick Kaja Hoyer Friederike Christen Jaspal Kaeda Matthias Obenaus Daniel Noerenberg Cornelius Hennch Willy Chan Yotaro Ochi Yuichi Shiraishi Yusuke Shiozawa Thorsten Zenz Christopher C. Oakes Birgit Sawitzki Michaela Schwarz Lars Bullinger Philipp le Coutre Matthew J. J. Rose-Zerilli Seishi Ogawa Frederik Damm Single-cell analysis based dissection of clonality in myelofibrosis |
| description |
Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations. |
| format |
article |
| author |
Elena Mylonas Kenichi Yoshida Mareike Frick Kaja Hoyer Friederike Christen Jaspal Kaeda Matthias Obenaus Daniel Noerenberg Cornelius Hennch Willy Chan Yotaro Ochi Yuichi Shiraishi Yusuke Shiozawa Thorsten Zenz Christopher C. Oakes Birgit Sawitzki Michaela Schwarz Lars Bullinger Philipp le Coutre Matthew J. J. Rose-Zerilli Seishi Ogawa Frederik Damm |
| author_facet |
Elena Mylonas Kenichi Yoshida Mareike Frick Kaja Hoyer Friederike Christen Jaspal Kaeda Matthias Obenaus Daniel Noerenberg Cornelius Hennch Willy Chan Yotaro Ochi Yuichi Shiraishi Yusuke Shiozawa Thorsten Zenz Christopher C. Oakes Birgit Sawitzki Michaela Schwarz Lars Bullinger Philipp le Coutre Matthew J. J. Rose-Zerilli Seishi Ogawa Frederik Damm |
| author_sort |
Elena Mylonas |
| title |
Single-cell analysis based dissection of clonality in myelofibrosis |
| title_short |
Single-cell analysis based dissection of clonality in myelofibrosis |
| title_full |
Single-cell analysis based dissection of clonality in myelofibrosis |
| title_fullStr |
Single-cell analysis based dissection of clonality in myelofibrosis |
| title_full_unstemmed |
Single-cell analysis based dissection of clonality in myelofibrosis |
| title_sort |
single-cell analysis based dissection of clonality in myelofibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37 |
| work_keys_str_mv |
AT elenamylonas singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT kenichiyoshida singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT mareikefrick singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT kajahoyer singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT friederikechristen singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT jaspalkaeda singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT matthiasobenaus singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT danielnoerenberg singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT corneliushennch singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT willychan singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT yotaroochi singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT yuichishiraishi singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT yusukeshiozawa singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT thorstenzenz singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT christophercoakes singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT birgitsawitzki singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT michaelaschwarz singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT larsbullinger singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT philipplecoutre singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT matthewjjrosezerilli singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT seishiogawa singlecellanalysisbaseddissectionofclonalityinmyelofibrosis AT frederikdamm singlecellanalysisbaseddissectionofclonalityinmyelofibrosis |
| _version_ |
1718380317930160128 |