Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show th...

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Autores principales:	Michael J. Holliday, Axel Witt, Alejandro Rodríguez Gama, Benjamin T. Walters, Christopher P. Arthur, Randal Halfmann, Alexis Rohou, Erin C. Dueber, Wayne J. Fairbrother
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
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spelling	oai:doaj.org-article:7e23aebac6c444bc92a15b78399d9b562021-12-02T14:39:04ZStructures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation10.1038/s41467-019-10953-z2041-1723https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b562019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10953-zhttps://doaj.org/toc/2041-1723CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show that the two proteins are activated through similar but distinct mechanisms.Michael J. HollidayAxel WittAlejandro Rodríguez GamaBenjamin T. WaltersChristopher P. ArthurRandal HalfmannAlexis RohouErin C. DueberWayne J. FairbrotherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
description	CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show that the two proteins are activated through similar but distinct mechanisms.
format	article
author	Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother
author_facet	Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother
author_sort	Michael J. Holliday
title	Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
title_short	Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
title_full	Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
title_fullStr	Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
title_full_unstemmed	Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
title_sort	structures of autoinhibited and polymerized forms of card9 reveal mechanisms of card9 and card11 activation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7e23aebac6c444bc92a15b78399d9b56
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Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

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