Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses

Abstract Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, conso...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Meihong Chen, Jie Zhang, Yun Chen, Yan Qiu, Zi Luo, Sixia Zhao, Lei Du, Dongbo Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e25d2f0cdc44bd4ac26c158481e8467
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e25d2f0cdc44bd4ac26c158481e8467
record_format	dspace
spelling	oai:doaj.org-article:7e25d2f0cdc44bd4ac26c158481e84672021-12-02T15:08:48ZHydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses10.1038/s41598-018-26335-22045-2322https://doaj.org/article/7e25d2f0cdc44bd4ac26c158481e84672018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26335-2https://doaj.org/toc/2045-2322Abstract Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. All these processes were attenuated in the presence of H2. We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors and circulating leukocytes. H2 attenuated H/R-induced production of hydroxyl radicals, up-regulation of colony-stimulating factors, and recruitment of neutrophils and M1 macrophages to lung tissues. However, H2 did not substantially affect the H/R-induced increase in erythropoietin or pulmonary artery remodeling. Our results suggest that H2 ameliorates H/R-induced lung injury by inhibiting hydroxyl radical production and inflammation in lungs. It may also prevent colony-stimulating factors from mobilizing progenitors in response to H/R-induced injury.Meihong ChenJie ZhangYun ChenYan QiuZi LuoSixia ZhaoLei DuDongbo TianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meihong Chen Jie Zhang Yun Chen Yan Qiu Zi Luo Sixia Zhao Lei Du Dongbo Tian Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
description	Abstract Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. All these processes were attenuated in the presence of H2. We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors and circulating leukocytes. H2 attenuated H/R-induced production of hydroxyl radicals, up-regulation of colony-stimulating factors, and recruitment of neutrophils and M1 macrophages to lung tissues. However, H2 did not substantially affect the H/R-induced increase in erythropoietin or pulmonary artery remodeling. Our results suggest that H2 ameliorates H/R-induced lung injury by inhibiting hydroxyl radical production and inflammation in lungs. It may also prevent colony-stimulating factors from mobilizing progenitors in response to H/R-induced injury.
format	article
author	Meihong Chen Jie Zhang Yun Chen Yan Qiu Zi Luo Sixia Zhao Lei Du Dongbo Tian
author_facet	Meihong Chen Jie Zhang Yun Chen Yan Qiu Zi Luo Sixia Zhao Lei Du Dongbo Tian
author_sort	Meihong Chen
title	Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
title_short	Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
title_full	Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
title_fullStr	Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
title_full_unstemmed	Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
title_sort	hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7e25d2f0cdc44bd4ac26c158481e8467
work_keys_str_mv	AT meihongchen hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT jiezhang hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT yunchen hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT yanqiu hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT ziluo hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT sixiazhao hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT leidu hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses AT dongbotian hydrogenprotectslungfromhypoxiareoxygenationinjurybyreducinghydroxylradicalproductionandinhibitinginflammatoryresponses
_version_	1718388008373190656

Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses

Ejemplares similares