Candidate genes of SARS-CoV-2 gender susceptibility

Abstract The severe acute respiratory syndrome coronavirus (SARS-CoV-2) initiated a global viral pandemic since late 2019. Understanding that Coronavirus disease (COVID-19) disproportionately affects men than women results in great challenges. Although there is a growing body of published study on t...

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Autores principales:	Cristina Russo, Giovanna Morello, Roberta Malaguarnera, Salvatore Piro, Debora Lo Furno, Lucia Malaguarnera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e26ab5b61604525b979edd7be338842
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spelling	oai:doaj.org-article:7e26ab5b61604525b979edd7be3388422021-11-14T12:23:29ZCandidate genes of SARS-CoV-2 gender susceptibility10.1038/s41598-021-01131-72045-2322https://doaj.org/article/7e26ab5b61604525b979edd7be3388422021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01131-7https://doaj.org/toc/2045-2322Abstract The severe acute respiratory syndrome coronavirus (SARS-CoV-2) initiated a global viral pandemic since late 2019. Understanding that Coronavirus disease (COVID-19) disproportionately affects men than women results in great challenges. Although there is a growing body of published study on this topic, effective explanations underlying these sex differences and their effects on the infection outcome still remain uncertain. We applied a holistic bioinformatics method to investigate molecular variations of known SARS-CoV-2 interacting human proteins mainly expressed in gonadal tissues (testis and ovary), allowing for the identification of potential genetic targets for this infection. Functional enrichment and interaction network analyses were also performed to better investigate the biological differences between testicular and ovarian responses in the SARS-CoV-2 infection, paying particular attention to genes linked to immune-related pathways, reactions of host cells after intracellular infection, steroid hormone biosynthesis, receptor signaling, and the complement cascade, in order to evaluate their potential association with sexual difference in the likelihood of infection and severity of symptoms. The analysis revealed that within the testis network TMPRSS2, ADAM10, SERPING1, and CCR5 were present, while within the ovary network we found BST2, GATA1, ENPEP, TLR4, TLR7, IRF1, and IRF2. Our findings could provide potential targets for forthcoming experimental investigation related to SARS-CoV-2 treatment.Cristina RussoGiovanna MorelloRoberta MalaguarneraSalvatore PiroDebora Lo FurnoLucia MalaguarneraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristina Russo Giovanna Morello Roberta Malaguarnera Salvatore Piro Debora Lo Furno Lucia Malaguarnera Candidate genes of SARS-CoV-2 gender susceptibility
description	Abstract The severe acute respiratory syndrome coronavirus (SARS-CoV-2) initiated a global viral pandemic since late 2019. Understanding that Coronavirus disease (COVID-19) disproportionately affects men than women results in great challenges. Although there is a growing body of published study on this topic, effective explanations underlying these sex differences and their effects on the infection outcome still remain uncertain. We applied a holistic bioinformatics method to investigate molecular variations of known SARS-CoV-2 interacting human proteins mainly expressed in gonadal tissues (testis and ovary), allowing for the identification of potential genetic targets for this infection. Functional enrichment and interaction network analyses were also performed to better investigate the biological differences between testicular and ovarian responses in the SARS-CoV-2 infection, paying particular attention to genes linked to immune-related pathways, reactions of host cells after intracellular infection, steroid hormone biosynthesis, receptor signaling, and the complement cascade, in order to evaluate their potential association with sexual difference in the likelihood of infection and severity of symptoms. The analysis revealed that within the testis network TMPRSS2, ADAM10, SERPING1, and CCR5 were present, while within the ovary network we found BST2, GATA1, ENPEP, TLR4, TLR7, IRF1, and IRF2. Our findings could provide potential targets for forthcoming experimental investigation related to SARS-CoV-2 treatment.
format	article
author	Cristina Russo Giovanna Morello Roberta Malaguarnera Salvatore Piro Debora Lo Furno Lucia Malaguarnera
author_facet	Cristina Russo Giovanna Morello Roberta Malaguarnera Salvatore Piro Debora Lo Furno Lucia Malaguarnera
author_sort	Cristina Russo
title	Candidate genes of SARS-CoV-2 gender susceptibility
title_short	Candidate genes of SARS-CoV-2 gender susceptibility
title_full	Candidate genes of SARS-CoV-2 gender susceptibility
title_fullStr	Candidate genes of SARS-CoV-2 gender susceptibility
title_full_unstemmed	Candidate genes of SARS-CoV-2 gender susceptibility
title_sort	candidate genes of sars-cov-2 gender susceptibility
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7e26ab5b61604525b979edd7be338842
work_keys_str_mv	AT cristinarusso candidategenesofsarscov2gendersusceptibility AT giovannamorello candidategenesofsarscov2gendersusceptibility AT robertamalaguarnera candidategenesofsarscov2gendersusceptibility AT salvatorepiro candidategenesofsarscov2gendersusceptibility AT deboralofurno candidategenesofsarscov2gendersusceptibility AT luciamalaguarnera candidategenesofsarscov2gendersusceptibility
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Candidate genes of SARS-CoV-2 gender susceptibility

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