Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content

To endow Ti-based orthopedic implants immunomodulatory capability and thus enhanced osseointegration, different amounts of Sr are doped in Na2TiO3 nanorods in the arrays with identical nanotopographic parameters (rod diameter, length and inter-rod spacing) by substitution of Na+ using hydrothermal t...

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Autores principales:	Dongmei Yu, Shuo Guo, Meng Yu, Wenwen Liu, Xiaokang Li, Dafu Chen, Bo Li, Zheng Guo, Yong Han
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Nanorods-patterned array Sr incorporation Macrophage polarization Osteogenetic function of osteoblast Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7e27f5eea7344684abcb7ec33f4e40f7
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spelling	oai:doaj.org-article:7e27f5eea7344684abcb7ec33f4e40f72021-11-28T04:35:23ZImmunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content2452-199X10.1016/j.bioactmat.2021.08.033https://doaj.org/article/7e27f5eea7344684abcb7ec33f4e40f72022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004096https://doaj.org/toc/2452-199XTo endow Ti-based orthopedic implants immunomodulatory capability and thus enhanced osseointegration, different amounts of Sr are doped in Na2TiO3 nanorods in the arrays with identical nanotopographic parameters (rod diameter, length and inter-rod spacing) by substitution of Na+ using hydrothermal treatment. The obtained arrays are denoted as STSr2, STSr4, and STSr7, where the arabic numbers indicate the incorporating amounts of Sr in Na2TiO3. The modulation effects of the Sr-doped nanorods arrays on macrophage polarization and osteogenetic functions of osteoblasts are investigated, together with the array without Sr (ST). Moreover, osseointegration of these arrays are also assayed in rat femoral condyles. Sr-doped nanorods arrays accelerate M1 (pro-inflammatory phenotype)-to-M2 (anti-inflammatory phenotype) transformation of the adhered macrophages, enhancing secretion of pro-osteogenetic cytokines and growth factors (TGF-β1 and BMP2), moreover, the Sr doped arrays directly enhance osteogenetic functions of osteoblasts. The enhancement of paracrine of M2 macrophages and osteogenetic function of osteoblasts is promoted with the increase of Sr incorporating amounts. Consequently, Sr doped arrays show significantly enhanced osseointegration in vivo compared to ST, and STSr7 exhibits the best performance. Our work sheds a new light on the design of surface chemical components and structures for orthopedic implants to enhance their osseointegration.Dongmei YuShuo GuoMeng YuWenwen LiuXiaokang LiDafu ChenBo LiZheng GuoYong HanKeAi Communications Co., Ltd.articleNanorods-patterned arraySr incorporationMacrophage polarizationOsteogenetic function of osteoblastOsseointegrationMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 323-334 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanorods-patterned array Sr incorporation Macrophage polarization Osteogenetic function of osteoblast Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Nanorods-patterned array Sr incorporation Macrophage polarization Osteogenetic function of osteoblast Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Dongmei Yu Shuo Guo Meng Yu Wenwen Liu Xiaokang Li Dafu Chen Bo Li Zheng Guo Yong Han Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
description	To endow Ti-based orthopedic implants immunomodulatory capability and thus enhanced osseointegration, different amounts of Sr are doped in Na2TiO3 nanorods in the arrays with identical nanotopographic parameters (rod diameter, length and inter-rod spacing) by substitution of Na+ using hydrothermal treatment. The obtained arrays are denoted as STSr2, STSr4, and STSr7, where the arabic numbers indicate the incorporating amounts of Sr in Na2TiO3. The modulation effects of the Sr-doped nanorods arrays on macrophage polarization and osteogenetic functions of osteoblasts are investigated, together with the array without Sr (ST). Moreover, osseointegration of these arrays are also assayed in rat femoral condyles. Sr-doped nanorods arrays accelerate M1 (pro-inflammatory phenotype)-to-M2 (anti-inflammatory phenotype) transformation of the adhered macrophages, enhancing secretion of pro-osteogenetic cytokines and growth factors (TGF-β1 and BMP2), moreover, the Sr doped arrays directly enhance osteogenetic functions of osteoblasts. The enhancement of paracrine of M2 macrophages and osteogenetic function of osteoblasts is promoted with the increase of Sr incorporating amounts. Consequently, Sr doped arrays show significantly enhanced osseointegration in vivo compared to ST, and STSr7 exhibits the best performance. Our work sheds a new light on the design of surface chemical components and structures for orthopedic implants to enhance their osseointegration.
format	article
author	Dongmei Yu Shuo Guo Meng Yu Wenwen Liu Xiaokang Li Dafu Chen Bo Li Zheng Guo Yong Han
author_facet	Dongmei Yu Shuo Guo Meng Yu Wenwen Liu Xiaokang Li Dafu Chen Bo Li Zheng Guo Yong Han
author_sort	Dongmei Yu
title	Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
title_short	Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
title_full	Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
title_fullStr	Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
title_full_unstemmed	Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content
title_sort	immunomodulation and osseointegration activities of na2tio3 nanorods-arrayed coatings doped with different sr content
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/7e27f5eea7344684abcb7ec33f4e40f7
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Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content

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