CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS

BACKGROUND AND OBJECTIVE: In β thalassemia major that begins in the first year of life, iron deposition after blood transfusion is undesired event that must be removed with iron chelators such as desferal. On the other hand, it is not collected information about the hearing impairment in the patient...

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Autores principales:	K Kiakojouri, A Tamaddoni, H Mahmoodi Nesheli, Z Jahanian Bahnemiri, SH Gholipour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	thalassemia desferal ferritin tympanometry hearing impairment Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7e28a97830c74b4c8a2a779e4d7e944a
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spelling	oai:doaj.org-article:7e28a97830c74b4c8a2a779e4d7e944a2021-11-10T09:07:50ZCORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS1561-41072251-7170https://doaj.org/article/7e28a97830c74b4c8a2a779e4d7e944a2008-12-01T00:00:00Zhttp://jbums.org/article-1-3101-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: In β thalassemia major that begins in the first year of life, iron deposition after blood transfusion is undesired event that must be removed with iron chelators such as desferal. On the other hand, it is not collected information about the hearing impairment in the patients who received desferal therapy The aim of this study was to assess the presence and absence of hearing impairment in β thalassemia major patients and its correlation with desferal and ferritin level.METHODS: This analytical study was performed on 100 thalassemic patients in Amirkola thalassemic center. Fifty patients had received regular desferal therapy (case group) and fifty patients had received irregular desferal therapy (control group). Age, sex, ferritin level, route of desferal therapy and educational level had been recorded for both groups. They have been evaluated for auditory quality with tympanometer and audiometer.FINDINGS: In the case group four patients (8%) and in control group eight patients (16%) had conductive hearing loss. It was not meaningful difference. Also in the two groups there were no meaningful correlation between ferritin level and hearing loss. Tympanometry had shown some disturbance in both groups seven patients (14%) and fifteen patients (30%) in case and control groups, respectively (p=0.029).CONCLUSION: The results of this study showed that adequate regular desferal therapy in β thalassemia major patients is not associated with hearing impairment.K Kiakojouri,A Tamaddoni,H Mahmoodi Nesheli,Z Jahanian BahnemiriSH GholipourBabol University of Medical Sciencesarticlethalassemiadesferalferritintympanometryhearing impairmentMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 5, Pp 48-53 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia desferal ferritin tympanometry hearing impairment Medicine R Medicine (General) R5-920
spellingShingle	thalassemia desferal ferritin tympanometry hearing impairment Medicine R Medicine (General) R5-920 K Kiakojouri, A Tamaddoni, H Mahmoodi Nesheli, Z Jahanian Bahnemiri SH Gholipour CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
description	BACKGROUND AND OBJECTIVE: In β thalassemia major that begins in the first year of life, iron deposition after blood transfusion is undesired event that must be removed with iron chelators such as desferal. On the other hand, it is not collected information about the hearing impairment in the patients who received desferal therapy The aim of this study was to assess the presence and absence of hearing impairment in β thalassemia major patients and its correlation with desferal and ferritin level.METHODS: This analytical study was performed on 100 thalassemic patients in Amirkola thalassemic center. Fifty patients had received regular desferal therapy (case group) and fifty patients had received irregular desferal therapy (control group). Age, sex, ferritin level, route of desferal therapy and educational level had been recorded for both groups. They have been evaluated for auditory quality with tympanometer and audiometer.FINDINGS: In the case group four patients (8%) and in control group eight patients (16%) had conductive hearing loss. It was not meaningful difference. Also in the two groups there were no meaningful correlation between ferritin level and hearing loss. Tympanometry had shown some disturbance in both groups seven patients (14%) and fifteen patients (30%) in case and control groups, respectively (p=0.029).CONCLUSION: The results of this study showed that adequate regular desferal therapy in β thalassemia major patients is not associated with hearing impairment.
format	article
author	K Kiakojouri, A Tamaddoni, H Mahmoodi Nesheli, Z Jahanian Bahnemiri SH Gholipour
author_facet	K Kiakojouri, A Tamaddoni, H Mahmoodi Nesheli, Z Jahanian Bahnemiri SH Gholipour
author_sort	K Kiakojouri,
title	CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
title_short	CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
title_full	CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
title_fullStr	CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
title_full_unstemmed	CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS
title_sort	correlation of hearing impairment with desferal and serum ferritin level in β thalassemia major patients
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/7e28a97830c74b4c8a2a779e4d7e944a
work_keys_str_mv	AT kkiakojouri correlationofhearingimpairmentwithdesferalandserumferritinlevelinbthalassemiamajorpatients AT atamaddoni correlationofhearingimpairmentwithdesferalandserumferritinlevelinbthalassemiamajorpatients AT hmahmoodinesheli correlationofhearingimpairmentwithdesferalandserumferritinlevelinbthalassemiamajorpatients AT zjahanianbahnemiri correlationofhearingimpairmentwithdesferalandserumferritinlevelinbthalassemiamajorpatients AT shgholipour correlationofhearingimpairmentwithdesferalandserumferritinlevelinbthalassemiamajorpatients
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CORRELATION OF HEARING IMPAIRMENT WITH DESFERAL AND SERUM FERRITIN LEVEL IN β THALASSEMIA MAJOR PATIENTS

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