Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis

Epilepsy is a chronic brain disease with dysfunctional brain networks, and electroencephalography (EEG) is an important tool for epileptogenic zone (EZ) identification, with rich information about frequencies. Different frequency oscillations have different contributions to brain function, and cross...

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Autores principales:	Xiaotong Liu, Fang Han, Rui Fu, Qingyun Wang, Guoming Luan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cross-frequency coupling temporal lobe epilepsy SEEG functional network epileptogenic zone Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7e28e3e568e342baa1d0877ff5489674
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id	oai:doaj.org-article:7e28e3e568e342baa1d0877ff5489674
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spelling	oai:doaj.org-article:7e28e3e568e342baa1d0877ff54896742021-11-16T07:38:29ZEpileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis1664-229510.3389/fneur.2021.764821https://doaj.org/article/7e28e3e568e342baa1d0877ff54896742021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.764821/fullhttps://doaj.org/toc/1664-2295Epilepsy is a chronic brain disease with dysfunctional brain networks, and electroencephalography (EEG) is an important tool for epileptogenic zone (EZ) identification, with rich information about frequencies. Different frequency oscillations have different contributions to brain function, and cross-frequency coupling (CFC) has been found to exist within brain regions. Cross-channel and inter-channel analysis should be both focused because they help to analyze how epilepsy networks change and also localize the EZ. In this paper, we analyzed long-term stereo-electroencephalography (SEEG) data from 17 patients with temporal lobe epilepsy. Single-channel and cross-channel CFC features were combined to establish functional brain networks, and the network characteristics under different periods and the localization of EZ were analyzed. It was observed that theta–gamma phase amplitude coupling (PAC) within the electrodes in the seizure region increased during the ictal (p < 0.05). Theta–gamma and delta–gamma PAC of cross-channel were enhanced in the early and mid-late ictal, respectively. It was also found that there was a strong cross-frequency coupling state between channels of EZ in the functional network during the ictal, along with a more regular network than interictal. The accuracy rate of EZ localization was 82.4%. Overall, the combination of single-channel and multi-channel cross-band coupling analysis can help identify seizures and localize EZ for temporal lobe epilepsy. Rhythmic coupling reveals a relationship between the functional network and the seizure status of epilepsy.Xiaotong LiuFang HanRui FuQingyun WangGuoming LuanFrontiers Media S.A.articlecross-frequency couplingtemporal lobe epilepsySEEGfunctional networkepileptogenic zoneNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cross-frequency coupling temporal lobe epilepsy SEEG functional network epileptogenic zone Neurology. Diseases of the nervous system RC346-429
spellingShingle	cross-frequency coupling temporal lobe epilepsy SEEG functional network epileptogenic zone Neurology. Diseases of the nervous system RC346-429 Xiaotong Liu Fang Han Rui Fu Qingyun Wang Guoming Luan Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
description	Epilepsy is a chronic brain disease with dysfunctional brain networks, and electroencephalography (EEG) is an important tool for epileptogenic zone (EZ) identification, with rich information about frequencies. Different frequency oscillations have different contributions to brain function, and cross-frequency coupling (CFC) has been found to exist within brain regions. Cross-channel and inter-channel analysis should be both focused because they help to analyze how epilepsy networks change and also localize the EZ. In this paper, we analyzed long-term stereo-electroencephalography (SEEG) data from 17 patients with temporal lobe epilepsy. Single-channel and cross-channel CFC features were combined to establish functional brain networks, and the network characteristics under different periods and the localization of EZ were analyzed. It was observed that theta–gamma phase amplitude coupling (PAC) within the electrodes in the seizure region increased during the ictal (p < 0.05). Theta–gamma and delta–gamma PAC of cross-channel were enhanced in the early and mid-late ictal, respectively. It was also found that there was a strong cross-frequency coupling state between channels of EZ in the functional network during the ictal, along with a more regular network than interictal. The accuracy rate of EZ localization was 82.4%. Overall, the combination of single-channel and multi-channel cross-band coupling analysis can help identify seizures and localize EZ for temporal lobe epilepsy. Rhythmic coupling reveals a relationship between the functional network and the seizure status of epilepsy.
format	article
author	Xiaotong Liu Fang Han Rui Fu Qingyun Wang Guoming Luan
author_facet	Xiaotong Liu Fang Han Rui Fu Qingyun Wang Guoming Luan
author_sort	Xiaotong Liu
title	Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
title_short	Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
title_full	Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
title_fullStr	Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
title_full_unstemmed	Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis
title_sort	epileptogenic zone location of temporal lobe epilepsy by cross-frequency coupling analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7e28e3e568e342baa1d0877ff5489674
work_keys_str_mv	AT xiaotongliu epileptogeniczonelocationoftemporallobeepilepsybycrossfrequencycouplinganalysis AT fanghan epileptogeniczonelocationoftemporallobeepilepsybycrossfrequencycouplinganalysis AT ruifu epileptogeniczonelocationoftemporallobeepilepsybycrossfrequencycouplinganalysis AT qingyunwang epileptogeniczonelocationoftemporallobeepilepsybycrossfrequencycouplinganalysis AT guomingluan epileptogeniczonelocationoftemporallobeepilepsybycrossfrequencycouplinganalysis
_version_	1718426612869890048

Epileptogenic Zone Location of Temporal Lobe Epilepsy by Cross-Frequency Coupling Analysis

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