Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced intra-clonal transcriptomic variability, likely...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander Nguyen, Mitsukuni Yoshida, Hani Goodarzi, Sohail F. Tavazoie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e299b798cc044399ba376b2b8746bde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e299b798cc044399ba376b2b8746bde
record_format	dspace
spelling	oai:doaj.org-article:7e299b798cc044399ba376b2b8746bde2021-12-02T17:31:48ZHighly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness10.1038/ncomms112462041-1723https://doaj.org/article/7e299b798cc044399ba376b2b8746bde2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11246https://doaj.org/toc/2041-1723Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced intra-clonal transcriptomic variability, likely promoted by deregulated spliceosome activity.Alexander NguyenMitsukuni YoshidaHani GoodarziSohail F. TavazoieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander Nguyen Mitsukuni Yoshida Hani Goodarzi Sohail F. Tavazoie Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
description	Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced intra-clonal transcriptomic variability, likely promoted by deregulated spliceosome activity.
format	article
author	Alexander Nguyen Mitsukuni Yoshida Hani Goodarzi Sohail F. Tavazoie
author_facet	Alexander Nguyen Mitsukuni Yoshida Hani Goodarzi Sohail F. Tavazoie
author_sort	Alexander Nguyen
title	Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
title_short	Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
title_full	Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
title_fullStr	Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
title_full_unstemmed	Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
title_sort	highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7e299b798cc044399ba376b2b8746bde
work_keys_str_mv	AT alexandernguyen highlyvariablecancersubpopulationsthatexhibitenhancedtranscriptomevariabilityandmetastaticfitness AT mitsukuniyoshida highlyvariablecancersubpopulationsthatexhibitenhancedtranscriptomevariabilityandmetastaticfitness AT hanigoodarzi highlyvariablecancersubpopulationsthatexhibitenhancedtranscriptomevariabilityandmetastaticfitness AT sohailftavazoie highlyvariablecancersubpopulationsthatexhibitenhancedtranscriptomevariabilityandmetastaticfitness
_version_	1718380500684374016

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

Ejemplares similares