Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness

Phenotypic and genetic intra-tumor heterogeneity have an important role in cancer progression and therapeutic resistance. Here, the authors show that phenotypically variable tumor subpopulations exhibit higher metastatic potential and display enhanced intra-clonal transcriptomic variability, likely...

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Autores principales: Alexander Nguyen, Mitsukuni Yoshida, Hani Goodarzi, Sohail F. Tavazoie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7e299b798cc044399ba376b2b8746bde
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