AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

AGO2 localizes to cytokinetic protrusions in a p38-dependent manner and is needed for accurate cell division

Pantazopoulou et al. find that AGO2 resides in open-ended tunneling nanotubes and close-ended cytokinetic bridges. At the latter location, AGO2 colocalizes with cell division components and the authors show that AGO2 depletion impairs cell division fidelity.

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Auteurs principaux: Vasiliki I. Pantazopoulou, Anastasios D. Delis, Stella Georgiou, Stamatis N. Pagakis, Vicky Filippa, Eleni Dragona, Ismini Kloukina, Elias Chatzitheodoridis, Jonel Trebicka, Athanassios D. Velentzas, Maja Thiele, Sarantis Gagos, Dimitris Thanos, Sofia Tseleni-Balafouta, Dimitrios J. Stravopodis, Ema Anastasiadou
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/7e2d246fce6f4d71b10947678754d0a9
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Résumé:Pantazopoulou et al. find that AGO2 resides in open-ended tunneling nanotubes and close-ended cytokinetic bridges. At the latter location, AGO2 colocalizes with cell division components and the authors show that AGO2 depletion impairs cell division fidelity.

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