Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group

Introduction: Multimorbidity often comes with age, making elderly people particularly prone to polypharmacy. Polypharmacy, in turn, is a risk factor for adverse drug reactions, drug-drug interactions, non-adherence to medication, negative health outcomes, and increased healthcare services utilizatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Przemysław Kardas, Aneta Lichwierowicz, Filip Urbański, Ewa Chudzyńska, Marcin Czech, Grzegorz Kardas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	polypharmacy potentially inappropriate prescribing drug safety elderly pharmacoepidemiology real-word data Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7e2dc330329c47088374f722920069e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e2dc330329c47088374f722920069e8
record_format	dspace
spelling	oai:doaj.org-article:7e2dc330329c47088374f722920069e82021-11-18T07:38:45ZPrevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group1663-981210.3389/fphar.2021.739740https://doaj.org/article/7e2dc330329c47088374f722920069e82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.739740/fullhttps://doaj.org/toc/1663-9812Introduction: Multimorbidity often comes with age, making elderly people particularly prone to polypharmacy. Polypharmacy, in turn, is a risk factor for adverse drug reactions, drug-drug interactions, non-adherence to medication, negative health outcomes, and increased healthcare services utilization. The longer the exposure to polypharmacy is, the higher the risk of these consequences is. Therefore, a detailed assessment of the prevalence and drivers of chronic polypharmacy in the elderly is particularly important.Aim of study: To find out the prevalence of chronic polypharmacy in the elderly population of Poland, and to characterize the subgroup with the highest risk of this problem, using real-world data.Methodology: A retrospective analysis of data on dispensation and healthcare services utilization held by the national payer organization for the year 2018. Chronic polypharmacy was defined as possession, as a result of dispensation, of five or more prescribed drugs within 80% of each of the consecutive 6 months.Results: Chronic polypharmacy was found in 554.1 thousand patients, i.e. in 19.1% of the national 65+ cohort. On average, those patients were 76 years old, and 49.3% of them were female. The vast majority (68.6%) continued their polypharmacy for the period of the whole year. There was a marked variation in geographical distribution of chronic polypharmacy with the highest value of 1.7 thousand per 100,000 inhabitants in the Łódź Voivodeship. Patients exposed to chronic polypharmacy filled prescriptions from 4.5±2.36 healthcare professionals. The average number of drugs they used was 8.3±3.84 DDD per patient per day. The most often prescribed drugs were Metformin, Atorvastatin and Pantoprazole. The average annual hospitalisation rate in those patients was 1.03±2.4.Conclusion: This study was the first of this kind involving a nationwide assessment of chronic polypharmacy in Polish elderly people. We found that this problem affected one fifth of Polish older adults and it remains stable due to its direct relation to chronic conditions. Thus, our results confirm that this phenomenon is highly important for the national health policy and requires relevant interventions. The planned introduction of pharmaceutical care in Poland is expected to help in solving the problem.Przemysław KardasAneta LichwierowiczFilip UrbańskiEwa ChudzyńskaMarcin CzechGrzegorz KardasFrontiers Media S.A.articlepolypharmacypotentially inappropriate prescribingdrug safetyelderlypharmacoepidemiologyreal-word dataTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polypharmacy potentially inappropriate prescribing drug safety elderly pharmacoepidemiology real-word data Therapeutics. Pharmacology RM1-950
spellingShingle	polypharmacy potentially inappropriate prescribing drug safety elderly pharmacoepidemiology real-word data Therapeutics. Pharmacology RM1-950 Przemysław Kardas Aneta Lichwierowicz Filip Urbański Ewa Chudzyńska Marcin Czech Grzegorz Kardas Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
description	Introduction: Multimorbidity often comes with age, making elderly people particularly prone to polypharmacy. Polypharmacy, in turn, is a risk factor for adverse drug reactions, drug-drug interactions, non-adherence to medication, negative health outcomes, and increased healthcare services utilization. The longer the exposure to polypharmacy is, the higher the risk of these consequences is. Therefore, a detailed assessment of the prevalence and drivers of chronic polypharmacy in the elderly is particularly important.Aim of study: To find out the prevalence of chronic polypharmacy in the elderly population of Poland, and to characterize the subgroup with the highest risk of this problem, using real-world data.Methodology: A retrospective analysis of data on dispensation and healthcare services utilization held by the national payer organization for the year 2018. Chronic polypharmacy was defined as possession, as a result of dispensation, of five or more prescribed drugs within 80% of each of the consecutive 6 months.Results: Chronic polypharmacy was found in 554.1 thousand patients, i.e. in 19.1% of the national 65+ cohort. On average, those patients were 76 years old, and 49.3% of them were female. The vast majority (68.6%) continued their polypharmacy for the period of the whole year. There was a marked variation in geographical distribution of chronic polypharmacy with the highest value of 1.7 thousand per 100,000 inhabitants in the Łódź Voivodeship. Patients exposed to chronic polypharmacy filled prescriptions from 4.5±2.36 healthcare professionals. The average number of drugs they used was 8.3±3.84 DDD per patient per day. The most often prescribed drugs were Metformin, Atorvastatin and Pantoprazole. The average annual hospitalisation rate in those patients was 1.03±2.4.Conclusion: This study was the first of this kind involving a nationwide assessment of chronic polypharmacy in Polish elderly people. We found that this problem affected one fifth of Polish older adults and it remains stable due to its direct relation to chronic conditions. Thus, our results confirm that this phenomenon is highly important for the national health policy and requires relevant interventions. The planned introduction of pharmaceutical care in Poland is expected to help in solving the problem.
format	article
author	Przemysław Kardas Aneta Lichwierowicz Filip Urbański Ewa Chudzyńska Marcin Czech Grzegorz Kardas
author_facet	Przemysław Kardas Aneta Lichwierowicz Filip Urbański Ewa Chudzyńska Marcin Czech Grzegorz Kardas
author_sort	Przemysław Kardas
title	Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
title_short	Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
title_full	Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
title_fullStr	Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
title_full_unstemmed	Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group
title_sort	prevalence of chronic polypharmacy in community-dwelling elderly people in poland: analysis of national real-world database helps to identify high risk group
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7e2dc330329c47088374f722920069e8
work_keys_str_mv	AT przemysławkardas prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup AT anetalichwierowicz prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup AT filipurbanski prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup AT ewachudzynska prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup AT marcinczech prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup AT grzegorzkardas prevalenceofchronicpolypharmacyincommunitydwellingelderlypeopleinpolandanalysisofnationalrealworlddatabasehelpstoidentifyhighriskgroup
_version_	1718423170457796608

Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group

Ejemplares similares