Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy
Abstract The purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions,...
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Nature Portfolio
2021
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oai:doaj.org-article:7e2eca5ea0a44fe88be17f0f3990b3452021-12-02T14:12:09ZShared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy10.1038/s41598-020-79565-82045-2322https://doaj.org/article/7e2eca5ea0a44fe88be17f0f3990b3452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79565-8https://doaj.org/toc/2045-2322Abstract The purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions, 32 benign lesions and 112 samples from the non-tumoral tissue (32 from chronic thyroiditis and 80 samples from colloid goiter) were subjected both to multivariate and univariate analysis. The increased succinate, glutamine, glutathione, serine/cysteine, ascorbate, lactate, taurine, threonine, glycine, phosphocholine/glycerophosphocholine and decreased lipids were found in both lesion types in comparison to either colloid goiter or chronic thyroiditis. The elevated glutamate and choline, and reduced citrate and glucose were additionally evident in these lesions in reference to goiter, while the increased myo-inositol—in comparison to thyroiditis. The malignant lesions were characterized by the higher alanine and lysine levels than colloid goiter and thyroiditis, while scyllo-inositol was uniquely increased in the benign lesions (not in cancer) in comparison to both non-tumoral tissue types. Moreover, the benign lesions presented with the unique increase of choline in reference to thyroiditis (not observed in the cancerous tissue). The metabolic heterogeneity of the non-tumoral tissue should be considered in the analysis of metabolic reprogramming in the thyroid lesions.Agnieszka SkorupaMateusz CiszekEwa ChmielikŁukasz BoguszewiczMałgorzata Oczko-WojciechowskaMałgorzata KowalskaDagmara RusinekTomasz TyszkiewiczAneta Kluczewska-GałkaAgnieszka CzarnieckaBarbara JarząbMaria SokółNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Agnieszka Skorupa Mateusz Ciszek Ewa Chmielik Łukasz Boguszewicz Małgorzata Oczko-Wojciechowska Małgorzata Kowalska Dagmara Rusinek Tomasz Tyszkiewicz Aneta Kluczewska-Gałka Agnieszka Czarniecka Barbara Jarząb Maria Sokół Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| description |
Abstract The purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions, 32 benign lesions and 112 samples from the non-tumoral tissue (32 from chronic thyroiditis and 80 samples from colloid goiter) were subjected both to multivariate and univariate analysis. The increased succinate, glutamine, glutathione, serine/cysteine, ascorbate, lactate, taurine, threonine, glycine, phosphocholine/glycerophosphocholine and decreased lipids were found in both lesion types in comparison to either colloid goiter or chronic thyroiditis. The elevated glutamate and choline, and reduced citrate and glucose were additionally evident in these lesions in reference to goiter, while the increased myo-inositol—in comparison to thyroiditis. The malignant lesions were characterized by the higher alanine and lysine levels than colloid goiter and thyroiditis, while scyllo-inositol was uniquely increased in the benign lesions (not in cancer) in comparison to both non-tumoral tissue types. Moreover, the benign lesions presented with the unique increase of choline in reference to thyroiditis (not observed in the cancerous tissue). The metabolic heterogeneity of the non-tumoral tissue should be considered in the analysis of metabolic reprogramming in the thyroid lesions. |
| format |
article |
| author |
Agnieszka Skorupa Mateusz Ciszek Ewa Chmielik Łukasz Boguszewicz Małgorzata Oczko-Wojciechowska Małgorzata Kowalska Dagmara Rusinek Tomasz Tyszkiewicz Aneta Kluczewska-Gałka Agnieszka Czarniecka Barbara Jarząb Maria Sokół |
| author_facet |
Agnieszka Skorupa Mateusz Ciszek Ewa Chmielik Łukasz Boguszewicz Małgorzata Oczko-Wojciechowska Małgorzata Kowalska Dagmara Rusinek Tomasz Tyszkiewicz Aneta Kluczewska-Gałka Agnieszka Czarniecka Barbara Jarząb Maria Sokół |
| author_sort |
Agnieszka Skorupa |
| title |
Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| title_short |
Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| title_full |
Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| title_fullStr |
Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| title_full_unstemmed |
Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy |
| title_sort |
shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1h hr mas nmr spectroscopy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7e2eca5ea0a44fe88be17f0f3990b345 |
| work_keys_str_mv |
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