Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T

Brain stress testing using blood oxygenation level-dependent (BOLD) MRI to evaluate changes in cerebrovascular reactivity (CVR) is of growing interest for evaluating white matter integrity. However, even under healthy conditions, the white matter BOLD-CVR response differs notably from that observed...

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Autor principal:	Alex A. Bhogal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cerebrovascular reactivity CVR White matter Hypercapnia 7 tesla MRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/7e31865aa98846a4a2b8ae8507cfbcdd
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spelling	oai:doaj.org-article:7e31865aa98846a4a2b8ae8507cfbcdd2021-12-02T04:59:33ZMedullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T1095-957210.1016/j.neuroimage.2021.118771https://doaj.org/article/7e31865aa98846a4a2b8ae8507cfbcdd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010430https://doaj.org/toc/1095-9572Brain stress testing using blood oxygenation level-dependent (BOLD) MRI to evaluate changes in cerebrovascular reactivity (CVR) is of growing interest for evaluating white matter integrity. However, even under healthy conditions, the white matter BOLD-CVR response differs notably from that observed in the gray matter. In addition to actual arterial vascular control, the venous draining topology may influence the WM-CVR response leading to signal delays and dispersions. These types of alterations in hemodynamic parameters are sometimes linked with pathology, but may also arise from differences in normal venous architecture. In this work, high-resolution T2*weighted anatomical images combined with BOLD imaging during a hypercapnic breathing protocol were acquired using a 7 tesla MRI system. Hemodynamic parameters including base CVR, hemodynamic lag, lag-corrected CVR, response onset and signal dispersion, and finally ΔCVR (corrected CVR minus base CVR) were calculated in 8 subjects. Parameter maps were spatially normalized and correlated against an MNI-registered white matter medullary vein atlas. Moderate correlations (Pearson's rho) were observed between medullary vessel frequency (MVF) and ΔCVR (0.52; 0.58 for total WM), MVF and hemodynamic lag (0.42; 0.54 for total WM), MVF and signal dispersion (0.44; 0.53 for total WM), and finally MVF and signal onset (0.43; 0.52 for total WM). Results indicate that, when assessed in the context of the WM venous architecture, changes in the response shape may only be partially reflective of the actual vascular reactivity response occurring further upstream by control vessels. This finding may have implications when attributing diseases mechanisms and/or progression to presumed impaired WM BOLD-CVR.Alex A. BhogalElsevierarticleCerebrovascular reactivityCVRWhite matterHypercapnia 7 teslaMRINeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118771- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerebrovascular reactivity CVR White matter Hypercapnia 7 tesla MRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Cerebrovascular reactivity CVR White matter Hypercapnia 7 tesla MRI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Alex A. Bhogal Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
description	Brain stress testing using blood oxygenation level-dependent (BOLD) MRI to evaluate changes in cerebrovascular reactivity (CVR) is of growing interest for evaluating white matter integrity. However, even under healthy conditions, the white matter BOLD-CVR response differs notably from that observed in the gray matter. In addition to actual arterial vascular control, the venous draining topology may influence the WM-CVR response leading to signal delays and dispersions. These types of alterations in hemodynamic parameters are sometimes linked with pathology, but may also arise from differences in normal venous architecture. In this work, high-resolution T2*weighted anatomical images combined with BOLD imaging during a hypercapnic breathing protocol were acquired using a 7 tesla MRI system. Hemodynamic parameters including base CVR, hemodynamic lag, lag-corrected CVR, response onset and signal dispersion, and finally ΔCVR (corrected CVR minus base CVR) were calculated in 8 subjects. Parameter maps were spatially normalized and correlated against an MNI-registered white matter medullary vein atlas. Moderate correlations (Pearson's rho) were observed between medullary vessel frequency (MVF) and ΔCVR (0.52; 0.58 for total WM), MVF and hemodynamic lag (0.42; 0.54 for total WM), MVF and signal dispersion (0.44; 0.53 for total WM), and finally MVF and signal onset (0.43; 0.52 for total WM). Results indicate that, when assessed in the context of the WM venous architecture, changes in the response shape may only be partially reflective of the actual vascular reactivity response occurring further upstream by control vessels. This finding may have implications when attributing diseases mechanisms and/or progression to presumed impaired WM BOLD-CVR.
format	article
author	Alex A. Bhogal
author_facet	Alex A. Bhogal
author_sort	Alex A. Bhogal
title	Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
title_short	Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
title_full	Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
title_fullStr	Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
title_full_unstemmed	Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T
title_sort	medullary vein architecture modulates the white matter bold cerebrovascular reactivity signal response to co2: observations from high-resolution t2* weighted imaging at 7t
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7e31865aa98846a4a2b8ae8507cfbcdd
work_keys_str_mv	AT alexabhogal medullaryveinarchitecturemodulatesthewhitematterboldcerebrovascularreactivitysignalresponsetoco2observationsfromhighresolutiont2weightedimagingat7t
_version_	1718400897656029184

Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2* weighted imaging at 7T

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