Total synthesis of Septocylindrin B and C-terminus modified analogues.

The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tes...

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Autores principales:	Jo Nelissen, Koen Nuyts, Marta De Zotti, Rob Lavigne, Chris Lamberigts, Wim M De Borggraeve
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e32673ec2db460780249e2e69781461
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spelling	oai:doaj.org-article:7e32673ec2db460780249e2e697814612021-11-18T08:04:23ZTotal synthesis of Septocylindrin B and C-terminus modified analogues.1932-620310.1371/journal.pone.0051708https://doaj.org/article/7e32673ec2db460780249e2e697814612012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284749/?tool=EBIhttps://doaj.org/toc/1932-6203The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.Jo NelissenKoen NuytsMarta De ZottiRob LavigneChris LamberigtsWim M De BorggraevePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51708 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jo Nelissen Koen Nuyts Marta De Zotti Rob Lavigne Chris Lamberigts Wim M De Borggraeve Total synthesis of Septocylindrin B and C-terminus modified analogues.
description	The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.
format	article
author	Jo Nelissen Koen Nuyts Marta De Zotti Rob Lavigne Chris Lamberigts Wim M De Borggraeve
author_facet	Jo Nelissen Koen Nuyts Marta De Zotti Rob Lavigne Chris Lamberigts Wim M De Borggraeve
author_sort	Jo Nelissen
title	Total synthesis of Septocylindrin B and C-terminus modified analogues.
title_short	Total synthesis of Septocylindrin B and C-terminus modified analogues.
title_full	Total synthesis of Septocylindrin B and C-terminus modified analogues.
title_fullStr	Total synthesis of Septocylindrin B and C-terminus modified analogues.
title_full_unstemmed	Total synthesis of Septocylindrin B and C-terminus modified analogues.
title_sort	total synthesis of septocylindrin b and c-terminus modified analogues.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7e32673ec2db460780249e2e69781461
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Total synthesis of Septocylindrin B and C-terminus modified analogues.

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