Total synthesis of Septocylindrin B and C-terminus modified analogues.

Total synthesis of Septocylindrin B and C-terminus modified analogues.

The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tes...

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Autores principales: Jo Nelissen, Koen Nuyts, Marta De Zotti, Rob Lavigne, Chris Lamberigts, Wim M De Borggraeve
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7e32673ec2db460780249e2e69781461
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