Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice
Boswellia sp. is a species of Boswellia. Burseraceae is an essential conventional natural product that has received a lot of attention in the pharmaceutical industry in recent years. The aim of this study was to role of Boswellia sp. Burseraceae on kidney and liver of Balb/c mice. Different concentr...
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2022
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oai:doaj.org-article:7e3366e2726e4e3fbbd5cf9c128012fa2021-11-22T04:18:35ZBiomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice1018-364710.1016/j.jksus.2021.101691https://doaj.org/article/7e3366e2726e4e3fbbd5cf9c128012fa2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003530https://doaj.org/toc/1018-3647Boswellia sp. is a species of Boswellia. Burseraceae is an essential conventional natural product that has received a lot of attention in the pharmaceutical industry in recent years. The aim of this study was to role of Boswellia sp. Burseraceae on kidney and liver of Balb/c mice. Different concentrations of Boswellia sp. Burseraceae solution was given to 5–7 weeks old wild-type Balb/c mice of both sexes (n = 24) for 21 days, with a control group given normal water to determine the physiological, biochemical, haematological, (0.5%, 1%), and histopathological effect of (0.5%, 1% and 5%) Boswellia sp..The results of this study showed that physiological parameters were changed with the increasing concentration of Boswellia sp. Burseraceae solution; like daily food consumption was reduced and fluid intake was more, decrease in body weight, urine output was low with less Na+ & K+ resulting into hypernatremia, hyperkalemia and hyperuricemia. Also elevated creatinine level in blood increase levels of bilirubin, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and degeneration of cells, glomerular atrophy of kidney cells and degeneration of hepatocytes. In conclusion, all of the results support to dosage toxicity. Biochemical indicators such as white blood cells, glucose, and haemoglobin did not alter significantly. Based on the findings, it is concluded that the extract exhibits dosage toxicity, which is corroborated by histopathological indicators.Saad H. AlotaibiOmaima NasirSalma ElsayedOmaima AhmedRoua S. BatySuzan A. AbushalNada AlqadriHiba OmerHamada H. AmerElsevierarticleBoswellia sp. BurseraceaePhysiologicalBiochemicalHistopathologicalDose toxicityScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101691- (2022) |
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Boswellia sp. Burseraceae Physiological Biochemical Histopathological Dose toxicity Science (General) Q1-390 |
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Boswellia sp. Burseraceae Physiological Biochemical Histopathological Dose toxicity Science (General) Q1-390 Saad H. Alotaibi Omaima Nasir Salma Elsayed Omaima Ahmed Roua S. Baty Suzan A. Abushal Nada Alqadri Hiba Omer Hamada H. Amer Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| description |
Boswellia sp. is a species of Boswellia. Burseraceae is an essential conventional natural product that has received a lot of attention in the pharmaceutical industry in recent years. The aim of this study was to role of Boswellia sp. Burseraceae on kidney and liver of Balb/c mice. Different concentrations of Boswellia sp. Burseraceae solution was given to 5–7 weeks old wild-type Balb/c mice of both sexes (n = 24) for 21 days, with a control group given normal water to determine the physiological, biochemical, haematological, (0.5%, 1%), and histopathological effect of (0.5%, 1% and 5%) Boswellia sp..The results of this study showed that physiological parameters were changed with the increasing concentration of Boswellia sp. Burseraceae solution; like daily food consumption was reduced and fluid intake was more, decrease in body weight, urine output was low with less Na+ & K+ resulting into hypernatremia, hyperkalemia and hyperuricemia. Also elevated creatinine level in blood increase levels of bilirubin, Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and degeneration of cells, glomerular atrophy of kidney cells and degeneration of hepatocytes. In conclusion, all of the results support to dosage toxicity. Biochemical indicators such as white blood cells, glucose, and haemoglobin did not alter significantly. Based on the findings, it is concluded that the extract exhibits dosage toxicity, which is corroborated by histopathological indicators. |
| format |
article |
| author |
Saad H. Alotaibi Omaima Nasir Salma Elsayed Omaima Ahmed Roua S. Baty Suzan A. Abushal Nada Alqadri Hiba Omer Hamada H. Amer |
| author_facet |
Saad H. Alotaibi Omaima Nasir Salma Elsayed Omaima Ahmed Roua S. Baty Suzan A. Abushal Nada Alqadri Hiba Omer Hamada H. Amer |
| author_sort |
Saad H. Alotaibi |
| title |
Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| title_short |
Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| title_full |
Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| title_fullStr |
Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| title_full_unstemmed |
Biomedical and histological evidence of Boswellia sp. Burseraceae on kidney and liver function in mice |
| title_sort |
biomedical and histological evidence of boswellia sp. burseraceae on kidney and liver function in mice |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://doaj.org/article/7e3366e2726e4e3fbbd5cf9c128012fa |
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