The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer

Colorectal cancer (CRC) ranks 2nd in the structure of mortality from malignant neoplasms (MN). One of the criteria for the prognosis of CRC may be a tumor stroma, which has not been widely used in clinical practice. The aim was to determine the main morphological features of the stroma CRC T3N0-2...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Alina Yakimenko
Formato:	article
Lenguaje:	EN
Publicado:	Scientific Route OÜ 2021
Materias:	stroma colorectal cancer recurrence prognosis Medicine R
Acceso en línea:	https://doaj.org/article/7e364c53420a4b9f8449bde6a267a40f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e364c53420a4b9f8449bde6a267a40f
record_format	dspace
spelling	oai:doaj.org-article:7e364c53420a4b9f8449bde6a267a40f2021-11-12T09:47:19ZThe role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer2585-66262585-663410.21303/2585-6634.2021.002139https://doaj.org/article/7e364c53420a4b9f8449bde6a267a40f2021-10-01T00:00:00Zhttp://journal.eu-jr.eu/ttism/article/view/2139https://doaj.org/toc/2585-6626https://doaj.org/toc/2585-6634Colorectal cancer (CRC) ranks 2nd in the structure of mortality from malignant neoplasms (MN). One of the criteria for the prognosis of CRC may be a tumor stroma, which has not been widely used in clinical practice. The aim was to determine the main morphological features of the stroma CRC T3N0-2M0 and search for prognostic criteria for their recurrence and lethal outcome according to the operating material and autopsy. Materials and methods. Group I included primary CRC without recurrence. The average recurrence-free period was 5 years (62.5±16.5 months). Group II – primary CRC with recurrence; IIA – with recurrences within 5 years from the date of tumor removal that did not lead to death; IIB – with the appearance of recurrence and lethal consequence of the generalization of the tumor process within 5 years from the moment of removal of the primary tumor. CRC micropreparations made according to the standard method with G + E staining were studied; immunohistochemical study was performed using monoclonal antibodies to smooth muscle actin alpha. Results. Stromal-parenchymal ratio >50 % is a prognostic criterion for recurrence (p<0.05) and shorter recurrence-free survival (p<0.001) of patients with stage IIA-IIIB CRC. Immature stroma type CRC stage IIA-IIIB is associated with the presence of tumor budding (p<0.001), G3 differentiation (p<0.01), shorter recurrence-free survival (p<0.001); among recurrent CRCs, the immature type of stroma is associated with the lethal outcome of patients (p<0.05). Expressed levels of tumor-activated fibroblasts are one of the criteria for immature CRC stroma (p<0.003), but as an independent prognostic criterion has limited prognostic value. Conclusions. TSR and immature type of stroma are prognostic criteria for recurrence and recurrence period of CRC pT3N0-2M0, more typical of tumors of patients with recurrence and lethal outcome with the same ratio of tumors by differentiation.Alina YakimenkoScientific Route OÜarticlestromacolorectal cancerrecurrenceprognosisMedicineRENTechnology Transfer: Innovative Solutions in Medicine, Pp 13-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroma colorectal cancer recurrence prognosis Medicine R
spellingShingle	stroma colorectal cancer recurrence prognosis Medicine R Alina Yakimenko The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
description	Colorectal cancer (CRC) ranks 2nd in the structure of mortality from malignant neoplasms (MN). One of the criteria for the prognosis of CRC may be a tumor stroma, which has not been widely used in clinical practice. The aim was to determine the main morphological features of the stroma CRC T3N0-2M0 and search for prognostic criteria for their recurrence and lethal outcome according to the operating material and autopsy. Materials and methods. Group I included primary CRC without recurrence. The average recurrence-free period was 5 years (62.5±16.5 months). Group II – primary CRC with recurrence; IIA – with recurrences within 5 years from the date of tumor removal that did not lead to death; IIB – with the appearance of recurrence and lethal consequence of the generalization of the tumor process within 5 years from the moment of removal of the primary tumor. CRC micropreparations made according to the standard method with G + E staining were studied; immunohistochemical study was performed using monoclonal antibodies to smooth muscle actin alpha. Results. Stromal-parenchymal ratio >50 % is a prognostic criterion for recurrence (p<0.05) and shorter recurrence-free survival (p<0.001) of patients with stage IIA-IIIB CRC. Immature stroma type CRC stage IIA-IIIB is associated with the presence of tumor budding (p<0.001), G3 differentiation (p<0.01), shorter recurrence-free survival (p<0.001); among recurrent CRCs, the immature type of stroma is associated with the lethal outcome of patients (p<0.05). Expressed levels of tumor-activated fibroblasts are one of the criteria for immature CRC stroma (p<0.003), but as an independent prognostic criterion has limited prognostic value. Conclusions. TSR and immature type of stroma are prognostic criteria for recurrence and recurrence period of CRC pT3N0-2M0, more typical of tumors of patients with recurrence and lethal outcome with the same ratio of tumors by differentiation.
format	article
author	Alina Yakimenko
author_facet	Alina Yakimenko
author_sort	Alina Yakimenko
title	The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
title_short	The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
title_full	The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
title_fullStr	The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
title_full_unstemmed	The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer
title_sort	role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage iia-iiib colorectal cancer
publisher	Scientific Route OÜ
publishDate	2021
url	https://doaj.org/article/7e364c53420a4b9f8449bde6a267a40f
work_keys_str_mv	AT alinayakimenko theroleoftumoralstromaindeterminingtheforecastofrecurrenceandfatalconsequenceofstageiiaiiibcolorectalcancer AT alinayakimenko roleoftumoralstromaindeterminingtheforecastofrecurrenceandfatalconsequenceofstageiiaiiibcolorectalcancer
_version_	1718431058815352832

The role of tumoral stroma in determining the forecast of recurrence and fatal consequence of stage IIA-IIIB colorectal cancer

Ejemplares similares