Chronic pain and mortality: a systematic review.

<h4>Background</h4>Chronic pain is common, often widespread and has a substantial impact on health and quality of life. The relationship between chronic pain and mortality is unclear. This systematic review aimed to identify and evaluate evidence for a relationship between chronic pain a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Diane Smith, Ross Wilkie, Olalekan Uthman, Joanne L Jordan, John McBeth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e3c9a6214af4232a610f4b918a13714
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e3c9a6214af4232a610f4b918a13714
record_format	dspace
spelling	oai:doaj.org-article:7e3c9a6214af4232a610f4b918a137142021-11-18T08:17:01ZChronic pain and mortality: a systematic review.1932-620310.1371/journal.pone.0099048https://doaj.org/article/7e3c9a6214af4232a610f4b918a137142014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901358/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Chronic pain is common, often widespread and has a substantial impact on health and quality of life. The relationship between chronic pain and mortality is unclear. This systematic review aimed to identify and evaluate evidence for a relationship between chronic pain and mortality.<h4>Methods</h4>A search of ten electronic databases including EMBASE and MEDLINE was conducted in March 2012, and updated until March 2014. Observational studies investigating the association between chronic or widespread pain (including fibromyalgia) and mortality were included. Risk of bias was assessed and a meta-analysis was undertaken to quantify heterogeneity and pool results. A narrative review was undertaken to explore similarities and differences between the included studies.<h4>Results</h4>Ten studies were included in the review. Three reported significant associations between chronic or widespread pain and mortality in unadjusted results. In adjusted analyses, four studies reported a significant association. The remaining studies reported no statistically significant association. A meta-analysis showed statistically significant heterogeneity of results from studies using comparable outcome measures (n = 7)(I2 = 78.8%) and a modest but non-significant pooled estimate (MRR1.14,95%CI 0.95-1.37) for the relationship between chronic pain and all-cause mortality. This association was stronger when analysis was restricted to studies of widespread pain (n = 5,I2 = 82.3%) MRR1.22(95%CI 0.93-1.60). The same pattern was observed with deaths from cancer and cardiovascular diseases. Heterogeneity is likely to be due to differences in study populations, follow-up time, pain phenotype, methods of analysis and use of confounding factors.<h4>Conclusion</h4>This review showed a mildly increased risk of death in people with chronic pain, particularly from cancer. However, the small number of studies and methodological differences prevented clear conclusions from being drawn. Consistently applied definitions of chronic pain and further investigation of the role of health, lifestyle, social and psychological factors in future studies will improve understanding of the relationship between chronic pain and mortality.Diane SmithRoss WilkieOlalekan UthmanJoanne L JordanJohn McBethPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99048 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Diane Smith Ross Wilkie Olalekan Uthman Joanne L Jordan John McBeth Chronic pain and mortality: a systematic review.
description	<h4>Background</h4>Chronic pain is common, often widespread and has a substantial impact on health and quality of life. The relationship between chronic pain and mortality is unclear. This systematic review aimed to identify and evaluate evidence for a relationship between chronic pain and mortality.<h4>Methods</h4>A search of ten electronic databases including EMBASE and MEDLINE was conducted in March 2012, and updated until March 2014. Observational studies investigating the association between chronic or widespread pain (including fibromyalgia) and mortality were included. Risk of bias was assessed and a meta-analysis was undertaken to quantify heterogeneity and pool results. A narrative review was undertaken to explore similarities and differences between the included studies.<h4>Results</h4>Ten studies were included in the review. Three reported significant associations between chronic or widespread pain and mortality in unadjusted results. In adjusted analyses, four studies reported a significant association. The remaining studies reported no statistically significant association. A meta-analysis showed statistically significant heterogeneity of results from studies using comparable outcome measures (n = 7)(I2 = 78.8%) and a modest but non-significant pooled estimate (MRR1.14,95%CI 0.95-1.37) for the relationship between chronic pain and all-cause mortality. This association was stronger when analysis was restricted to studies of widespread pain (n = 5,I2 = 82.3%) MRR1.22(95%CI 0.93-1.60). The same pattern was observed with deaths from cancer and cardiovascular diseases. Heterogeneity is likely to be due to differences in study populations, follow-up time, pain phenotype, methods of analysis and use of confounding factors.<h4>Conclusion</h4>This review showed a mildly increased risk of death in people with chronic pain, particularly from cancer. However, the small number of studies and methodological differences prevented clear conclusions from being drawn. Consistently applied definitions of chronic pain and further investigation of the role of health, lifestyle, social and psychological factors in future studies will improve understanding of the relationship between chronic pain and mortality.
format	article
author	Diane Smith Ross Wilkie Olalekan Uthman Joanne L Jordan John McBeth
author_facet	Diane Smith Ross Wilkie Olalekan Uthman Joanne L Jordan John McBeth
author_sort	Diane Smith
title	Chronic pain and mortality: a systematic review.
title_short	Chronic pain and mortality: a systematic review.
title_full	Chronic pain and mortality: a systematic review.
title_fullStr	Chronic pain and mortality: a systematic review.
title_full_unstemmed	Chronic pain and mortality: a systematic review.
title_sort	chronic pain and mortality: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7e3c9a6214af4232a610f4b918a13714
work_keys_str_mv	AT dianesmith chronicpainandmortalityasystematicreview AT rosswilkie chronicpainandmortalityasystematicreview AT olalekanuthman chronicpainandmortalityasystematicreview AT joanneljordan chronicpainandmortalityasystematicreview AT johnmcbeth chronicpainandmortalityasystematicreview
_version_	1718421994809065472

Chronic pain and mortality: a systematic review.

Ejemplares similares