Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia

Jingwei Lu, Vincent J Pompili, Hiranmoy DasCardiovascular Stem Cell Research Laboratory, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USAAbstract: Despite recent advances in cardiovascular medicine, ischemic heart disease remain...

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Autores principales:	Jingwei Lu, Vincent J Pompili, Hiranmoy Das
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/7e41a3189e2c4134b3d76558da5712be
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spelling	oai:doaj.org-article:7e41a3189e2c4134b3d76558da5712be2021-12-02T08:11:58ZHematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia1178-6957https://doaj.org/article/7e41a3189e2c4134b3d76558da5712be2010-03-01T00:00:00Zhttp://www.dovepress.com/hematopoietic-stem-cells-ex-vivo-expansion-and-therapeutic-potential-f-a4156https://doaj.org/toc/1178-6957Jingwei Lu, Vincent J Pompili, Hiranmoy DasCardiovascular Stem Cell Research Laboratory, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USAAbstract: Despite recent advances in cardiovascular medicine, ischemic heart disease remains the major cause of death in the United States and abroad. Cell-based therapy for degenerative diseases like myocardial ischemia using stem cells is currently under serious investigation. Various types of stem cells are being considered to be candidates for cell transplantation in cell-based therapy. Hematopoietic stem cells are one of the most promising cell types as several studies demonstrated their ability to improve ischemic cardiac functions by enhancing neovascularization and by reducing the total size of scar tissue. However, in order to procure sufficient numbers of functional stem cells, ex-vivo expansion technology became critically important. In this review, we focus on the state-of-the-art ex-vivo technology for the expansion of hematopoietic stem cells, and the underlying mechanisms regulating stem cell self-renewal as well as differentiation.Keywords: ischemic heart disease, ex-vivo expansion, hematopoietic stem cells, cytokines, nanofibers Jingwei LuVincent J PompiliHiranmoy DasDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 57-68 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Jingwei Lu Vincent J Pompili Hiranmoy Das Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
description	Jingwei Lu, Vincent J Pompili, Hiranmoy DasCardiovascular Stem Cell Research Laboratory, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USAAbstract: Despite recent advances in cardiovascular medicine, ischemic heart disease remains the major cause of death in the United States and abroad. Cell-based therapy for degenerative diseases like myocardial ischemia using stem cells is currently under serious investigation. Various types of stem cells are being considered to be candidates for cell transplantation in cell-based therapy. Hematopoietic stem cells are one of the most promising cell types as several studies demonstrated their ability to improve ischemic cardiac functions by enhancing neovascularization and by reducing the total size of scar tissue. However, in order to procure sufficient numbers of functional stem cells, ex-vivo expansion technology became critically important. In this review, we focus on the state-of-the-art ex-vivo technology for the expansion of hematopoietic stem cells, and the underlying mechanisms regulating stem cell self-renewal as well as differentiation.Keywords: ischemic heart disease, ex-vivo expansion, hematopoietic stem cells, cytokines, nanofibers
format	article
author	Jingwei Lu Vincent J Pompili Hiranmoy Das
author_facet	Jingwei Lu Vincent J Pompili Hiranmoy Das
author_sort	Jingwei Lu
title	Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
title_short	Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
title_full	Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
title_fullStr	Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
title_full_unstemmed	Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
title_sort	hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/7e41a3189e2c4134b3d76558da5712be
work_keys_str_mv	AT jingweilu hematopoieticstemcellsexvivoexpansionandtherapeuticpotentialformyocardialischemia AT vincentjpompili hematopoieticstemcellsexvivoexpansionandtherapeuticpotentialformyocardialischemia AT hiranmoydas hematopoieticstemcellsexvivoexpansionandtherapeuticpotentialformyocardialischemia
_version_	1718398608562192384

Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia

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