Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata

Amitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment and therefore they are released to rivers, estuaries and coastal waters. The pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Esther Blanco-Rayón, Haizea Ziarrusta, Leire Mijangos, Maitane Olivares, Olatz Zuloaga, Nestor Etxebarria, Urtzi Izagirre
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Gilt-head seabream Biomarkers Lysosomes AMI Ecology QH540-549.5
Acceso en línea:	https://doaj.org/article/7e4358aca57e461488d1aef8edfcf3b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e4358aca57e461488d1aef8edfcf3b5
record_format	dspace
spelling	oai:doaj.org-article:7e4358aca57e461488d1aef8edfcf3b52021-12-01T04:58:13ZIntegrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata1470-160X10.1016/j.ecolind.2021.108028https://doaj.org/article/7e4358aca57e461488d1aef8edfcf3b52021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1470160X21006932https://doaj.org/toc/1470-160XAmitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment and therefore they are released to rivers, estuaries and coastal waters. The presence of this kind of compounds in the water environment may involve a negative impact on non-target aquatic organisms at relatively low concentrations. However, the knowledge of AMI effects on aquatic organisms in the environment is scarce. Thus, the objective of this work is to determine the effects of environmentally-relevant concentrations of AMI on biological responses at biochemical and cellular levels in marine teleost. Gilt-head seabream (S. aurata) were exposed to AMI for 7 days at 0.2 μg/L in an open flow system and a battery of biomarkers were investigated: acetylcholinesterase, catalase, superoxide dismutase, glutathione S-transferase, cytochrome C oxidase, P450 CYP1A1 ethoxyresorufin (O) dealkylation, and lysosomal biomarkers. Biomarkers were integrated as IBR/n (biological response index). Overall, it can be concluded that AMI exposure at environmentally-relevant concentration induces significant biological responses to stress in marine teleost, especially in lysosomal biomarkers. However, further research is needed about the effects of AMI and other pharmaceuticals on biomarkers in non-targeted species, to raise the knowledge about the toxicity of this type of emerging pollutants.Esther Blanco-RayónHaizea ZiarrustaLeire MijangosMaitane OlivaresOlatz ZuloagaNestor EtxebarriaUrtzi IzagirreElsevierarticleGilt-head seabreamBiomarkersLysosomesAMIEcologyQH540-549.5ENEcological Indicators, Vol 130, Iss , Pp 108028- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gilt-head seabream Biomarkers Lysosomes AMI Ecology QH540-549.5
spellingShingle	Gilt-head seabream Biomarkers Lysosomes AMI Ecology QH540-549.5 Esther Blanco-Rayón Haizea Ziarrusta Leire Mijangos Maitane Olivares Olatz Zuloaga Nestor Etxebarria Urtzi Izagirre Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
description	Amitriptyline (AMI) is a commonly tricyclic antidepressant to treat depression, anxiety, and other conditions. Like many other pharmaceuticals, AMI and its by-products are incompletely removed during wastewater treatment and therefore they are released to rivers, estuaries and coastal waters. The presence of this kind of compounds in the water environment may involve a negative impact on non-target aquatic organisms at relatively low concentrations. However, the knowledge of AMI effects on aquatic organisms in the environment is scarce. Thus, the objective of this work is to determine the effects of environmentally-relevant concentrations of AMI on biological responses at biochemical and cellular levels in marine teleost. Gilt-head seabream (S. aurata) were exposed to AMI for 7 days at 0.2 μg/L in an open flow system and a battery of biomarkers were investigated: acetylcholinesterase, catalase, superoxide dismutase, glutathione S-transferase, cytochrome C oxidase, P450 CYP1A1 ethoxyresorufin (O) dealkylation, and lysosomal biomarkers. Biomarkers were integrated as IBR/n (biological response index). Overall, it can be concluded that AMI exposure at environmentally-relevant concentration induces significant biological responses to stress in marine teleost, especially in lysosomal biomarkers. However, further research is needed about the effects of AMI and other pharmaceuticals on biomarkers in non-targeted species, to raise the knowledge about the toxicity of this type of emerging pollutants.
format	article
author	Esther Blanco-Rayón Haizea Ziarrusta Leire Mijangos Maitane Olivares Olatz Zuloaga Nestor Etxebarria Urtzi Izagirre
author_facet	Esther Blanco-Rayón Haizea Ziarrusta Leire Mijangos Maitane Olivares Olatz Zuloaga Nestor Etxebarria Urtzi Izagirre
author_sort	Esther Blanco-Rayón
title	Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
title_short	Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
title_full	Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
title_fullStr	Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
title_full_unstemmed	Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata
title_sort	integrated biological response to environmentally-relevant concentration of amitriptyline in sparus aurata
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7e4358aca57e461488d1aef8edfcf3b5
work_keys_str_mv	AT estherblancorayon integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT haizeaziarrusta integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT leiremijangos integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT maitaneolivares integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT olatzzuloaga integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT nestoretxebarria integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata AT urtziizagirre integratedbiologicalresponsetoenvironmentallyrelevantconcentrationofamitriptylineinsparusaurata
_version_	1718405670458359808

Integrated biological response to environmentally-relevant concentration of amitriptyline in Sparus aurata

Ejemplares similares