Granzyme A produced by γ(9)δ(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.
Human γ(9)δ(2) T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. We report a novel mechanism involving the inhibition of intracellular mycobacteria by soluble granzyme A. γ(9)δ(2) T cells produce...
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Main Authors: | Charles T Spencer, Getahun Abate, Isaac G Sakala, Mei Xia, Steven M Truscott, Christopher S Eickhoff, Rebecca Linn, Azra Blazevic, Sunil S Metkar, Guangyong Peng, Christopher J Froelich, Daniel F Hoft |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Online Access: | https://doaj.org/article/7e461b845d7349aa8572e4c47139d982 |
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