Granzyme A produced by γ(9)δ(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen.

Human γ(9)δ(2) T cells potently inhibit pathogenic microbes, including intracellular mycobacteria, but the key inhibitory mechanism(s) involved have not been identified. We report a novel mechanism involving the inhibition of intracellular mycobacteria by soluble granzyme A. γ(9)δ(2) T cells produce...

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Bibliographic Details
Main Authors: Charles T Spencer, Getahun Abate, Isaac G Sakala, Mei Xia, Steven M Truscott, Christopher S Eickhoff, Rebecca Linn, Azra Blazevic, Sunil S Metkar, Guangyong Peng, Christopher J Froelich, Daniel F Hoft
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
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Online Access:https://doaj.org/article/7e461b845d7349aa8572e4c47139d982
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