Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease

Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third Affiliated Hospital, Sun Yat-Sen University,...

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Autores principales:	Wang J, Chen X, Men X, Chen M, Tao J, Lu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cerebral vascular disease sleep polysomnography fragmentation markers Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/7e483de8f6f54b0b8ed47e2a050bc34e
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spelling	oai:doaj.org-article:7e483de8f6f54b0b8ed47e2a050bc34e2021-12-02T05:31:16ZChronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease1179-1608https://doaj.org/article/7e483de8f6f54b0b8ed47e2a050bc34e2020-02-01T00:00:00Zhttps://www.dovepress.com/chronic-insomnia-is-associated-with-higher-circulating-interleukin-8-i-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of ChinaCorrespondence: Jiong TaoDepartment of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, No.600 Tianhe Road, Tianhe District, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +8613600071635Email tj2023@163.comZhengqi LuDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, No.600 Tianhe Road, Tianhe District, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +8618922102767Email lzq1828@outlook.comObjective: Chronic inflammatory responses and leukocyte infiltration are classical pathological features of cerebral small vessel disease (CSVD). To date, limited evidence of a relationship between chronic insomnia and inflammatory responses in patients with CSVD has been uncovered. The purpose of the present study was to investigate the potential relationship between chronic insomnia and pro-inflammatory cytokine levels in patients with atherosclerotic CSVD (A-CSVD).Methods: In total, 76 A-CSVD patients with or without chronic insomnia (CI) confirmed using magnetic resonance (MR) were prospectively recruited. Overnight polysomnography (PSG) was performed and serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-8, and IL-12 assessed. Cytokine levels were compared between CSVD+CI (study group) and CSVD without CI (control group) patients, and the correlations between PSG parameters and cytokine levels were explored in all patients via multiple linear regression analyses.Results: The serum IL-8 level of the study group (12.3± 4.4 pg/mL) was significantly higher than that of the control group (7.5± 2.2 pg/mL; P< 0.05). PSG measurements showed that patients in the study group had significantly higher sleep onset latency (SOL), arousal index (ArI) and wake after sleep onset (WASO) as well as lower total sleep time (TST), sleep efficiency (SE) and stage 3 NREM sleep (N-3) ratio, compared with the control group (P< 0.05). Multiple linear regression analyses led to the identification of ArI (β=0.026, P< 0.05) and TST (β=− 0.054, P< 0.05) as significant positive and negative predictors of the IL-8 level, respectively.Conclusion: Chronic insomnia, in particular, sleep fragmentation and short sleep duration, may be involved in promotion of serum IL-8 expression in patients with atherosclerotic CSVD.Keywords: cerebral vascular disease, sleep, polysomnography, fragmentation, markersWang JChen XMen XChen MTao JLu ZDove Medical Pressarticlecerebral vascular diseasesleeppolysomnographyfragmentationmarkersPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 93-99 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebral vascular disease sleep polysomnography fragmentation markers Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	cerebral vascular disease sleep polysomnography fragmentation markers Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Wang J Chen X Men X Chen M Tao J Lu Z Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
description	Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of ChinaCorrespondence: Jiong TaoDepartment of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, No.600 Tianhe Road, Tianhe District, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +8613600071635Email tj2023@163.comZhengqi LuDepartment of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, No.600 Tianhe Road, Tianhe District, Guangzhou, Guangdong 510630, People’s Republic of ChinaTel +8618922102767Email lzq1828@outlook.comObjective: Chronic inflammatory responses and leukocyte infiltration are classical pathological features of cerebral small vessel disease (CSVD). To date, limited evidence of a relationship between chronic insomnia and inflammatory responses in patients with CSVD has been uncovered. The purpose of the present study was to investigate the potential relationship between chronic insomnia and pro-inflammatory cytokine levels in patients with atherosclerotic CSVD (A-CSVD).Methods: In total, 76 A-CSVD patients with or without chronic insomnia (CI) confirmed using magnetic resonance (MR) were prospectively recruited. Overnight polysomnography (PSG) was performed and serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-17A, IL-8, and IL-12 assessed. Cytokine levels were compared between CSVD+CI (study group) and CSVD without CI (control group) patients, and the correlations between PSG parameters and cytokine levels were explored in all patients via multiple linear regression analyses.Results: The serum IL-8 level of the study group (12.3± 4.4 pg/mL) was significantly higher than that of the control group (7.5± 2.2 pg/mL; P< 0.05). PSG measurements showed that patients in the study group had significantly higher sleep onset latency (SOL), arousal index (ArI) and wake after sleep onset (WASO) as well as lower total sleep time (TST), sleep efficiency (SE) and stage 3 NREM sleep (N-3) ratio, compared with the control group (P< 0.05). Multiple linear regression analyses led to the identification of ArI (β=0.026, P< 0.05) and TST (β=− 0.054, P< 0.05) as significant positive and negative predictors of the IL-8 level, respectively.Conclusion: Chronic insomnia, in particular, sleep fragmentation and short sleep duration, may be involved in promotion of serum IL-8 expression in patients with atherosclerotic CSVD.Keywords: cerebral vascular disease, sleep, polysomnography, fragmentation, markers
format	article
author	Wang J Chen X Men X Chen M Tao J Lu Z
author_facet	Wang J Chen X Men X Chen M Tao J Lu Z
author_sort	Wang J
title	Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
title_short	Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
title_full	Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
title_fullStr	Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
title_full_unstemmed	Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease
title_sort	chronic insomnia is associated with higher circulating interleukin-8 in patients with atherosclerotic cerebral small vessel disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7e483de8f6f54b0b8ed47e2a050bc34e
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Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease

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