Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia

Introduction: preeclampsia/eclampsia contributed to 30% of maternal mortality in RSUP Dr. Kariadi. Pre-induction bishop score assessment is a standard for cervical maturity estimation. Other predictors currently being developed, including insulin-like growth factor binding protein-1 (IGFBP-1). Howev...

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Autores principales:	Nurul Setiyorini, Ratnasari Dwi Cahyanti
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2021
Materias:	preeclampsia, labor induction, insulin-like growth factor binding protein-1, bishop score Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7e4ea8e91adc4382bc917901aa957d3a
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spelling	oai:doaj.org-article:7e4ea8e91adc4382bc917901aa957d3a2021-11-25T13:16:44ZComparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia2085-15452339-093X10.30659/sainsmed.v11i2.10919https://doaj.org/article/7e4ea8e91adc4382bc917901aa957d3a2021-01-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/10919https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: preeclampsia/eclampsia contributed to 30% of maternal mortality in RSUP Dr. Kariadi. Pre-induction bishop score assessment is a standard for cervical maturity estimation. Other predictors currently being developed, including insulin-like growth factor binding protein-1 (IGFBP-1). However, there is no cut-off point for IGFBP-1 examination in full term pregnancy, especially with preeclampsia and its complications. Objective: to find IGFBP-1 levels and Bishop Score differences in preeclampsia women with induction labor. Methods: this prospective observational cohort study was conducted in preeclampsia women with gestational age ≥37 weeks planned labor induction at Obstetrics and Gynecology Ward RSUP Dr. Kariadi Semarang and networking hospital during study period (n=66). History taking, physical examination, proteinuria, cervical mucus IGFBP-1, and bishop score calculation was performed. Statistical analysis was performed with paired-t test, followed by ROC for cut-off value of successful induction prediction, and logistic regression to determine confounding variables effect on IGFBP-1 levels. Results: The average Bishop score of 66 subjects was 2.5±1.81 and 2.6±1.8 for women who deliver ≤24 labor and in labor for ≤12 hours, respectively. Although the bishop score was higher in the successful labor group, there was no significant difference between groups. Mean IGFBP-1 value was 8.29±5.033 mcg/L with median value of 10.8 mcg/L. Successful induction had significant higher IGFBP-1 levels with area-under-curve (AUC) 0.76 and 8.145 cutoff value (p=0.002, RR=5.1). Conclusion: IGFBP-1 level with cutoff point 8.145 can be used as predictor of successful labor induction in term pregnancy with preeclampsia.Nurul SetiyoriniRatnasari Dwi CahyantiUniversitas Sultan Agung Semarangarticlepreeclampsia, labor induction, insulin-like growth factor binding protein-1, bishop scoreMedicine (General)R5-920ENSains Medika, Vol 11, Iss 2, Pp 59-66 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preeclampsia, labor induction, insulin-like growth factor binding protein-1, bishop score Medicine (General) R5-920
spellingShingle	preeclampsia, labor induction, insulin-like growth factor binding protein-1, bishop score Medicine (General) R5-920 Nurul Setiyorini Ratnasari Dwi Cahyanti Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
description	Introduction: preeclampsia/eclampsia contributed to 30% of maternal mortality in RSUP Dr. Kariadi. Pre-induction bishop score assessment is a standard for cervical maturity estimation. Other predictors currently being developed, including insulin-like growth factor binding protein-1 (IGFBP-1). However, there is no cut-off point for IGFBP-1 examination in full term pregnancy, especially with preeclampsia and its complications. Objective: to find IGFBP-1 levels and Bishop Score differences in preeclampsia women with induction labor. Methods: this prospective observational cohort study was conducted in preeclampsia women with gestational age ≥37 weeks planned labor induction at Obstetrics and Gynecology Ward RSUP Dr. Kariadi Semarang and networking hospital during study period (n=66). History taking, physical examination, proteinuria, cervical mucus IGFBP-1, and bishop score calculation was performed. Statistical analysis was performed with paired-t test, followed by ROC for cut-off value of successful induction prediction, and logistic regression to determine confounding variables effect on IGFBP-1 levels. Results: The average Bishop score of 66 subjects was 2.5±1.81 and 2.6±1.8 for women who deliver ≤24 labor and in labor for ≤12 hours, respectively. Although the bishop score was higher in the successful labor group, there was no significant difference between groups. Mean IGFBP-1 value was 8.29±5.033 mcg/L with median value of 10.8 mcg/L. Successful induction had significant higher IGFBP-1 levels with area-under-curve (AUC) 0.76 and 8.145 cutoff value (p=0.002, RR=5.1). Conclusion: IGFBP-1 level with cutoff point 8.145 can be used as predictor of successful labor induction in term pregnancy with preeclampsia.
format	article
author	Nurul Setiyorini Ratnasari Dwi Cahyanti
author_facet	Nurul Setiyorini Ratnasari Dwi Cahyanti
author_sort	Nurul Setiyorini
title	Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
title_short	Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
title_full	Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
title_fullStr	Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
title_full_unstemmed	Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia
title_sort	comparison between insulin-like growth factor binding protein-1 level and bishop score as predictor of successful labor induction in full term pregnancy with preeclampsia
publisher	Universitas Sultan Agung Semarang
publishDate	2021
url	https://doaj.org/article/7e4ea8e91adc4382bc917901aa957d3a
work_keys_str_mv	AT nurulsetiyorini comparisonbetweeninsulinlikegrowthfactorbindingprotein1levelandbishopscoreaspredictorofsuccessfullaborinductioninfulltermpregnancywithpreeclampsia AT ratnasaridwicahyanti comparisonbetweeninsulinlikegrowthfactorbindingprotein1levelandbishopscoreaspredictorofsuccessfullaborinductioninfulltermpregnancywithpreeclampsia
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Comparison between Insulin-like Growth Factor Binding Protein-1 Level and Bishop Score as Predictor of Successful Labor Induction in Full Term Pregnancy with Preeclampsia

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