Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs

Despite significant efforts, there are currently no approved treatments for COVID-19. However, biotechnological approaches appear to be promising in the treatment of the disease. Accordingly, nucleic acid-based treatments including aptamers and siRNAs are candidates that might be effective in COVID-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Javad Khanali, Mohammadreza Azangou-Khyavy, Yasaman Asaadi, Monire Jamalkhah, Jafar Kiani
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aptamer COVID-19 RNA interference aptamer–siRNA chimera siRNA virus neutralization Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7e4f89db29b8400abb79b0b40c66dfea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e4f89db29b8400abb79b0b40c66dfea
record_format	dspace
spelling	oai:doaj.org-article:7e4f89db29b8400abb79b0b40c66dfea2021-11-08T15:15:45ZNucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs1664-302X10.3389/fmicb.2021.758948https://doaj.org/article/7e4f89db29b8400abb79b0b40c66dfea2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.758948/fullhttps://doaj.org/toc/1664-302XDespite significant efforts, there are currently no approved treatments for COVID-19. However, biotechnological approaches appear to be promising in the treatment of the disease. Accordingly, nucleic acid-based treatments including aptamers and siRNAs are candidates that might be effective in COVID-19 treatment. Aptamers can hamper entry and replication stages of the SARS-CoV-2 infection, while siRNAs can cleave the viral genomic and subgenomic RNAs to inhibit the viral life cycle and reduce viral loads. As a conjugated molecule, aptamer–siRNA chimeras have proven to be dual-functioning antiviral therapy, acting both as virus-neutralizing and replication-interfering agents as well as being a siRNA targeted delivery approach. Previous successful applications of these compounds against various stages of the pathogenesis of diseases and viral infections, besides their advantages over other alternatives, might provide sufficient rationale for the application of these nucleic acid-based drugs against the SARS-CoV-2. However, none of them are devoid of limitations. Here, the literature was reviewed to assess the plausibility of using aptamers, siRNAs, and aptamer–siRNA chimeras against the SARS-CoV-2 based on their previously established effectiveness, and discussing challenges lie in applying these molecules.Javad KhanaliMohammadreza Azangou-KhyavyYasaman AsaadiMonire JamalkhahMonire JamalkhahJafar KianiFrontiers Media S.A.articleaptamerCOVID-19RNA interferenceaptamer–siRNA chimerasiRNAvirus neutralizationMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aptamer COVID-19 RNA interference aptamer–siRNA chimera siRNA virus neutralization Microbiology QR1-502
spellingShingle	aptamer COVID-19 RNA interference aptamer–siRNA chimera siRNA virus neutralization Microbiology QR1-502 Javad Khanali Mohammadreza Azangou-Khyavy Yasaman Asaadi Monire Jamalkhah Monire Jamalkhah Jafar Kiani Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
description	Despite significant efforts, there are currently no approved treatments for COVID-19. However, biotechnological approaches appear to be promising in the treatment of the disease. Accordingly, nucleic acid-based treatments including aptamers and siRNAs are candidates that might be effective in COVID-19 treatment. Aptamers can hamper entry and replication stages of the SARS-CoV-2 infection, while siRNAs can cleave the viral genomic and subgenomic RNAs to inhibit the viral life cycle and reduce viral loads. As a conjugated molecule, aptamer–siRNA chimeras have proven to be dual-functioning antiviral therapy, acting both as virus-neutralizing and replication-interfering agents as well as being a siRNA targeted delivery approach. Previous successful applications of these compounds against various stages of the pathogenesis of diseases and viral infections, besides their advantages over other alternatives, might provide sufficient rationale for the application of these nucleic acid-based drugs against the SARS-CoV-2. However, none of them are devoid of limitations. Here, the literature was reviewed to assess the plausibility of using aptamers, siRNAs, and aptamer–siRNA chimeras against the SARS-CoV-2 based on their previously established effectiveness, and discussing challenges lie in applying these molecules.
format	article
author	Javad Khanali Mohammadreza Azangou-Khyavy Yasaman Asaadi Monire Jamalkhah Monire Jamalkhah Jafar Kiani
author_facet	Javad Khanali Mohammadreza Azangou-Khyavy Yasaman Asaadi Monire Jamalkhah Monire Jamalkhah Jafar Kiani
author_sort	Javad Khanali
title	Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
title_short	Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
title_full	Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
title_fullStr	Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
title_full_unstemmed	Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
title_sort	nucleic acid-based treatments against covid-19: potential efficacy of aptamers and sirnas
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7e4f89db29b8400abb79b0b40c66dfea
work_keys_str_mv	AT javadkhanali nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas AT mohammadrezaazangoukhyavy nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas AT yasamanasaadi nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas AT monirejamalkhah nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas AT monirejamalkhah nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas AT jafarkiani nucleicacidbasedtreatmentsagainstcovid19potentialefficacyofaptamersandsirnas
_version_	1718442148342267904

Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs

Ejemplares similares