Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction

Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of LRS–RagD protein–protein interaction.

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Autores principales:	Jonghoon Kim, Jinjoo Jung, Jaeyoung Koo, Wansang Cho, Won Seok Lee, Chanwoo Kim, Wonwoo Park, Seung Bum Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e52f32495c24dccba3aaf635457ccfe
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id	oai:doaj.org-article:7e52f32495c24dccba3aaf635457ccfe
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spelling	oai:doaj.org-article:7e52f32495c24dccba3aaf635457ccfe2021-12-02T15:35:24ZDiversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction10.1038/ncomms131962041-1723https://doaj.org/article/7e52f32495c24dccba3aaf635457ccfe2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13196https://doaj.org/toc/2041-1723Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of LRS–RagD protein–protein interaction.Jonghoon KimJinjoo JungJaeyoung KooWansang ChoWon Seok LeeChanwoo KimWonwoo ParkSeung Bum ParkNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonghoon Kim Jinjoo Jung Jaeyoung Koo Wansang Cho Won Seok Lee Chanwoo Kim Wonwoo Park Seung Bum Park Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
description	Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of LRS–RagD protein–protein interaction.
format	article
author	Jonghoon Kim Jinjoo Jung Jaeyoung Koo Wansang Cho Won Seok Lee Chanwoo Kim Wonwoo Park Seung Bum Park
author_facet	Jonghoon Kim Jinjoo Jung Jaeyoung Koo Wansang Cho Won Seok Lee Chanwoo Kim Wonwoo Park Seung Bum Park
author_sort	Jonghoon Kim
title	Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
title_short	Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
title_full	Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
title_fullStr	Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
title_full_unstemmed	Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
title_sort	diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7e52f32495c24dccba3aaf635457ccfe
work_keys_str_mv	AT jonghoonkim diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT jinjoojung diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT jaeyoungkoo diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT wansangcho diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT wonseoklee diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT chanwookim diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT wonwoopark diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction AT seungbumpark diversityorientedsyntheticstrategyfordevelopingachemicalmodulatorofproteinproteininteraction
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Diversity-oriented synthetic strategy for developing a chemical modulator of protein–protein interaction

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