Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a...

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Autores principales:	Camille Houron, Dragos Ciocan, Nicolas Trainel, Françoise Mercier-Nomé, Cindy Hugot, Madeleine Spatz, Gabriel Perlemuter, Anne-Marie Cassard
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NAFLD NASH fecal microbiota transplantation SCFA fiber pectin Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7e56a85fb9ab4340938cfb65d10e4187
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spelling	oai:doaj.org-article:7e56a85fb9ab4340938cfb65d10e41872021-11-25T18:33:30ZGut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice10.3390/nu131137252072-6643https://doaj.org/article/7e56a85fb9ab4340938cfb65d10e41872021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3725https://doaj.org/toc/2072-6643Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a fecal microbiota transfer (FMT). Mice fed a high-fat diet, which induces NAFLD, were treated with pectin or received a fecal microbiota transfer (FMT) from mice treated with pectin before (preventive FMT) or after (curative FMT) being fed a high-fat diet. Pectin prevented the development of NAFLD, induced browning of adipose tissue, and modified the IM without increasing the abundance of proteobacteria. Preventive FMT also induced browning of white adipose tissue but did not improve liver steatosis, in contrast to curative FMT, which induced an improvement in steatosis. This was associated with an increase in the concentration of short-chain fatty acids (SCFAs), in contrast to preventive FMT, which induced an increase in the concentration of branched SCFAs. Overall, we show that the effect of pectin may be partially mediated by gut bacteria.Camille HouronDragos CiocanNicolas TrainelFrançoise Mercier-NoméCindy HugotMadeleine SpatzGabriel PerlemuterAnne-Marie CassardMDPI AGarticleNAFLDNASHfecal microbiota transplantationSCFAfiberpectinNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3725, p 3725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NAFLD NASH fecal microbiota transplantation SCFA fiber pectin Nutrition. Foods and food supply TX341-641
spellingShingle	NAFLD NASH fecal microbiota transplantation SCFA fiber pectin Nutrition. Foods and food supply TX341-641 Camille Houron Dragos Ciocan Nicolas Trainel Françoise Mercier-Nomé Cindy Hugot Madeleine Spatz Gabriel Perlemuter Anne-Marie Cassard Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
description	Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a fecal microbiota transfer (FMT). Mice fed a high-fat diet, which induces NAFLD, were treated with pectin or received a fecal microbiota transfer (FMT) from mice treated with pectin before (preventive FMT) or after (curative FMT) being fed a high-fat diet. Pectin prevented the development of NAFLD, induced browning of adipose tissue, and modified the IM without increasing the abundance of proteobacteria. Preventive FMT also induced browning of white adipose tissue but did not improve liver steatosis, in contrast to curative FMT, which induced an improvement in steatosis. This was associated with an increase in the concentration of short-chain fatty acids (SCFAs), in contrast to preventive FMT, which induced an increase in the concentration of branched SCFAs. Overall, we show that the effect of pectin may be partially mediated by gut bacteria.
format	article
author	Camille Houron Dragos Ciocan Nicolas Trainel Françoise Mercier-Nomé Cindy Hugot Madeleine Spatz Gabriel Perlemuter Anne-Marie Cassard
author_facet	Camille Houron Dragos Ciocan Nicolas Trainel Françoise Mercier-Nomé Cindy Hugot Madeleine Spatz Gabriel Perlemuter Anne-Marie Cassard
author_sort	Camille Houron
title	Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
title_short	Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
title_full	Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
title_fullStr	Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
title_full_unstemmed	Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice
title_sort	gut microbiota reshaped by pectin treatment improves liver steatosis in obese mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e56a85fb9ab4340938cfb65d10e4187
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Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

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