Characteristics and resolution of hypertension in obese African American bariatric cohort

Abstract Weight reduction continues to be first-line therapy in the treatment of hypertension (HTN). However, the long-term effect of bariatric malabsorptive surgical techniques such as Roux-en-Y Gastric Bypass (RYGB) surgery in the management of hypertension (HTN) is less clear. African Americans (...

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Autores principales:	Charu Gandotra, Motahar Basam, Ankit Mahajan, Julius Ngwa, Gezzer Ortega, Daniel Tran, Terrence M. Fullum, Zaki A. Sherif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e5b255bd47c45a59dd1e25d178b89a1
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spelling	oai:doaj.org-article:7e5b255bd47c45a59dd1e25d178b89a12021-12-02T10:49:29ZCharacteristics and resolution of hypertension in obese African American bariatric cohort10.1038/s41598-021-81360-y2045-2322https://doaj.org/article/7e5b255bd47c45a59dd1e25d178b89a12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81360-yhttps://doaj.org/toc/2045-2322Abstract Weight reduction continues to be first-line therapy in the treatment of hypertension (HTN). However, the long-term effect of bariatric malabsorptive surgical techniques such as Roux-en-Y Gastric Bypass (RYGB) surgery in the management of hypertension (HTN) is less clear. African Americans (AA) are disproportionately affected by obesity and hypertension and have inconsistent outcomes after bariatric surgery (BS). Despite a plethora of bariatric literature, data about characteristics of a predominantly AA bariatric hypertensive cohort including hypertension in obese (HIO) are scarce and underreported. The aims of this study were, (1) to describe the preoperative clinical characteristics of HIO with respect to HTN status and age, and (2) to identify predictors of HTN resolution one year after RYGB surgery in an AA bariatric cohort enrolled at the Howard University Center for Wellness and Weight Loss Surgery (HUCWWS). In the review of 169 AA bariatric patients, the average BMI was 48.50 kg/m2 and the average age was 43.86 years. Obese hypertensive patients were older (46 years vs. 37.89 years; p < .0001); had higher prevalence of diabetes mellitus (DM, 43.09% vs. 10.87%; p < .0001) and dyslipidemia (38.2% vs. 13.04%; p 0.002). Hypertensive AA who were taking ≥ 2 antihypertensive medications prior to RYGB were 18 times less likely to experience HTN resolution compared to hypertensive AA taking 0–1 medications, who showed full or partial response. Also, HIO was less likely to resolve after RYGB surgery in patients who needed ≥ 2 antihypertensive medications prior to surgical intervention.Charu GandotraMotahar BasamAnkit MahajanJulius NgwaGezzer OrtegaDaniel TranTerrence M. FullumZaki A. SherifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charu Gandotra Motahar Basam Ankit Mahajan Julius Ngwa Gezzer Ortega Daniel Tran Terrence M. Fullum Zaki A. Sherif Characteristics and resolution of hypertension in obese African American bariatric cohort
description	Abstract Weight reduction continues to be first-line therapy in the treatment of hypertension (HTN). However, the long-term effect of bariatric malabsorptive surgical techniques such as Roux-en-Y Gastric Bypass (RYGB) surgery in the management of hypertension (HTN) is less clear. African Americans (AA) are disproportionately affected by obesity and hypertension and have inconsistent outcomes after bariatric surgery (BS). Despite a plethora of bariatric literature, data about characteristics of a predominantly AA bariatric hypertensive cohort including hypertension in obese (HIO) are scarce and underreported. The aims of this study were, (1) to describe the preoperative clinical characteristics of HIO with respect to HTN status and age, and (2) to identify predictors of HTN resolution one year after RYGB surgery in an AA bariatric cohort enrolled at the Howard University Center for Wellness and Weight Loss Surgery (HUCWWS). In the review of 169 AA bariatric patients, the average BMI was 48.50 kg/m2 and the average age was 43.86 years. Obese hypertensive patients were older (46 years vs. 37.89 years; p < .0001); had higher prevalence of diabetes mellitus (DM, 43.09% vs. 10.87%; p < .0001) and dyslipidemia (38.2% vs. 13.04%; p 0.002). Hypertensive AA who were taking ≥ 2 antihypertensive medications prior to RYGB were 18 times less likely to experience HTN resolution compared to hypertensive AA taking 0–1 medications, who showed full or partial response. Also, HIO was less likely to resolve after RYGB surgery in patients who needed ≥ 2 antihypertensive medications prior to surgical intervention.
format	article
author	Charu Gandotra Motahar Basam Ankit Mahajan Julius Ngwa Gezzer Ortega Daniel Tran Terrence M. Fullum Zaki A. Sherif
author_facet	Charu Gandotra Motahar Basam Ankit Mahajan Julius Ngwa Gezzer Ortega Daniel Tran Terrence M. Fullum Zaki A. Sherif
author_sort	Charu Gandotra
title	Characteristics and resolution of hypertension in obese African American bariatric cohort
title_short	Characteristics and resolution of hypertension in obese African American bariatric cohort
title_full	Characteristics and resolution of hypertension in obese African American bariatric cohort
title_fullStr	Characteristics and resolution of hypertension in obese African American bariatric cohort
title_full_unstemmed	Characteristics and resolution of hypertension in obese African American bariatric cohort
title_sort	characteristics and resolution of hypertension in obese african american bariatric cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7e5b255bd47c45a59dd1e25d178b89a1
work_keys_str_mv	AT charugandotra characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT motaharbasam characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT ankitmahajan characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT juliusngwa characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT gezzerortega characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT danieltran characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT terrencemfullum characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort AT zakiasherif characteristicsandresolutionofhypertensioninobeseafricanamericanbariatriccohort
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Characteristics and resolution of hypertension in obese African American bariatric cohort

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