Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.

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Autores principales: Hema Adhikari, Christopher M. Counter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd
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spelling oai:doaj.org-article:7e5f938bdb20449ab562ac01126223dd2021-12-02T16:56:53ZInterrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability10.1038/s41467-018-05692-62041-1723https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05692-6https://doaj.org/toc/2041-1723RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.Hema AdhikariChristopher M. CounterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hema Adhikari
Christopher M. Counter
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
description RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.
format article
author Hema Adhikari
Christopher M. Counter
author_facet Hema Adhikari
Christopher M. Counter
author_sort Hema Adhikari
title Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_short Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_full Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_fullStr Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_full_unstemmed Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_sort interrogating the protein interactomes of ras isoforms identifies pip5k1a as a kras-specific vulnerability
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd
work_keys_str_mv AT hemaadhikari interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability
AT christophermcounter interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability
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