Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.
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Nature Portfolio
2018
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oai:doaj.org-article:7e5f938bdb20449ab562ac01126223dd2021-12-02T16:56:53ZInterrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability10.1038/s41467-018-05692-62041-1723https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05692-6https://doaj.org/toc/2041-1723RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.Hema AdhikariChristopher M. CounterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
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Science Q Hema Adhikari Christopher M. Counter Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
description |
RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth. |
format |
article |
author |
Hema Adhikari Christopher M. Counter |
author_facet |
Hema Adhikari Christopher M. Counter |
author_sort |
Hema Adhikari |
title |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
title_short |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
title_full |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
title_fullStr |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
title_full_unstemmed |
Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability |
title_sort |
interrogating the protein interactomes of ras isoforms identifies pip5k1a as a kras-specific vulnerability |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd |
work_keys_str_mv |
AT hemaadhikari interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability AT christophermcounter interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability |
_version_ |
1718382690427731968 |