Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.

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Autores principales:	Hema Adhikari, Christopher M. Counter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd
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spelling	oai:doaj.org-article:7e5f938bdb20449ab562ac01126223dd2021-12-02T16:56:53ZInterrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability10.1038/s41467-018-05692-62041-1723https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05692-6https://doaj.org/toc/2041-1723RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.Hema AdhikariChristopher M. CounterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hema Adhikari Christopher M. Counter Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
description	RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth.
format	article
author	Hema Adhikari Christopher M. Counter
author_facet	Hema Adhikari Christopher M. Counter
author_sort	Hema Adhikari
title	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_short	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_full	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_fullStr	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_full_unstemmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
title_sort	interrogating the protein interactomes of ras isoforms identifies pip5k1a as a kras-specific vulnerability
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7e5f938bdb20449ab562ac01126223dd
work_keys_str_mv	AT hemaadhikari interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability AT christophermcounter interrogatingtheproteininteractomesofrasisoformsidentifiespip5k1aasakrasspecificvulnerability
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Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

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