Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

Joanna Jaroch,1 Olga Vriz,2 Zbigniew Bociąga,1 Caterina Driussi,2 Maria Łoboz-Rudnicka,1 Barbara Rzyczkowska,1 Krystyna Łoboz-Grudzień1,3 1Department of Cardiology, T Marciniak Hospital, Wroclaw, Poland; 2Division of Cardiology, San Antonio Hospital, San Daniele del Friuli...

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Autores principales:	Jaroch J, Vriz O, Bociąga Z, Driussi C, Łoboz-Rudnicka M, Rzyczkowska B, Łoboz-Grudzień K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	sex differences left ventricular diastolic dysfunction hypertension Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7e62002c5e6941928e25aeea5afd83c2
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spelling	oai:doaj.org-article:7e62002c5e6941928e25aeea5afd83c22021-12-02T04:47:30ZSex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension1178-1998https://doaj.org/article/7e62002c5e6941928e25aeea5afd83c22016-10-01T00:00:00Zhttps://www.dovepress.com/sex-specific-predictors-of-left-ventricular-diastolic-dysfunction-in-u-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Joanna Jaroch,1 Olga Vriz,2 Zbigniew Bociąga,1 Caterina Driussi,2 Maria Łoboz-Rudnicka,1 Barbara Rzyczkowska,1 Krystyna Łoboz-Grudzień1,3 1Department of Cardiology, T Marciniak Hospital, Wroclaw, Poland; 2Division of Cardiology, San Antonio Hospital, San Daniele del Friuli, Udine, Italy; 3Health Science Faculty, Wroclaw Medical University, Wroclaw, PolandBackground: Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We hypothesized that arterial stiffness (AS) may play a different role in the etiology of LV DD in hypertensive men and postmenopausal women, acting independently from other established predictors of this condition, such as age, obesity, diabetes mellitus, LV remodeling, and systolic function.Objectives: The aim of the study was to analyze the sex-specific differences in AS and other predictors of LV DD in men and postmenopausal women with untreated hypertension (HTN).Patients and methods: The study included 144 patients (63 postmenopausal women and 81 men, mean age 62.7±6.7 years) with previously untreated HTN and no history of cardiovascular diseases. All patients were subjected to detailed echocardiography, vascular ultrasound, and high-resolution echotracking (eTracking) of carotid arteries.Results: In the multivariate analysis, concomitant diabetes mellitus turned out to be an independent predictor of LV DD in women (P=0.02). In turn, two independent predictors of LV DD have been identified in men: S'-tissue Doppler-derived peak LV longitudinal systolic shortening velocity (P=0.001) and β, beta stiffness index (P=0.004).Conclusion: There are sex differences in the predictors of LV DD in untreated HTN. In postmenopausal women, LV DD is mostly determined by diabetes, while in men, it is determined by S', reflecting LV systolic longitudinal function, and β, a parameter of AS. Keywords: sex differences, left ventricular diastolic dysfunction, hypertensionJaroch JVriz OBociąga ZDriussi CŁoboz-Rudnicka MRzyczkowska BŁoboz-Grudzień KDove Medical Pressarticlesex differencesleft ventricular diastolic dysfunctionhypertensionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1495-1504 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	sex differences left ventricular diastolic dysfunction hypertension Geriatrics RC952-954.6
spellingShingle	sex differences left ventricular diastolic dysfunction hypertension Geriatrics RC952-954.6 Jaroch J Vriz O Bociąga Z Driussi C Łoboz-Rudnicka M Rzyczkowska B Łoboz-Grudzień K Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
description	Joanna Jaroch,1 Olga Vriz,2 Zbigniew Bociąga,1 Caterina Driussi,2 Maria Łoboz-Rudnicka,1 Barbara Rzyczkowska,1 Krystyna Łoboz-Grudzień1,3 1Department of Cardiology, T Marciniak Hospital, Wroclaw, Poland; 2Division of Cardiology, San Antonio Hospital, San Daniele del Friuli, Udine, Italy; 3Health Science Faculty, Wroclaw Medical University, Wroclaw, PolandBackground: Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We hypothesized that arterial stiffness (AS) may play a different role in the etiology of LV DD in hypertensive men and postmenopausal women, acting independently from other established predictors of this condition, such as age, obesity, diabetes mellitus, LV remodeling, and systolic function.Objectives: The aim of the study was to analyze the sex-specific differences in AS and other predictors of LV DD in men and postmenopausal women with untreated hypertension (HTN).Patients and methods: The study included 144 patients (63 postmenopausal women and 81 men, mean age 62.7±6.7 years) with previously untreated HTN and no history of cardiovascular diseases. All patients were subjected to detailed echocardiography, vascular ultrasound, and high-resolution echotracking (eTracking) of carotid arteries.Results: In the multivariate analysis, concomitant diabetes mellitus turned out to be an independent predictor of LV DD in women (P=0.02). In turn, two independent predictors of LV DD have been identified in men: S'-tissue Doppler-derived peak LV longitudinal systolic shortening velocity (P=0.001) and β, beta stiffness index (P=0.004).Conclusion: There are sex differences in the predictors of LV DD in untreated HTN. In postmenopausal women, LV DD is mostly determined by diabetes, while in men, it is determined by S', reflecting LV systolic longitudinal function, and β, a parameter of AS. Keywords: sex differences, left ventricular diastolic dysfunction, hypertension
format	article
author	Jaroch J Vriz O Bociąga Z Driussi C Łoboz-Rudnicka M Rzyczkowska B Łoboz-Grudzień K
author_facet	Jaroch J Vriz O Bociąga Z Driussi C Łoboz-Rudnicka M Rzyczkowska B Łoboz-Grudzień K
author_sort	Jaroch J
title	Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
title_short	Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
title_full	Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
title_fullStr	Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
title_full_unstemmed	Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
title_sort	sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7e62002c5e6941928e25aeea5afd83c2
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Sex-specific predictors of left ventricular diastolic dysfunction in untreated hypertension

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