TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

Inflammation is a component of Parkinson’s disease. Here the authors show that activation of Toll-like receptor 9 controlled by microglial glucocorticoid receptor signaling, contributes to dopamine neuron loss in a model of Parkinson’s disease.

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Autores principales:	Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N. Trawick, Richard M. Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vyas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e620af317d44ae895a31e6a05dc755b
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spelling	oai:doaj.org-article:7e620af317d44ae895a31e6a05dc755b2021-12-02T15:34:26ZTLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons10.1038/s41467-018-04569-y2041-1723https://doaj.org/article/7e620af317d44ae895a31e6a05dc755b2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04569-yhttps://doaj.org/toc/2041-1723Inflammation is a component of Parkinson’s disease. Here the authors show that activation of Toll-like receptor 9 controlled by microglial glucocorticoid receptor signaling, contributes to dopamine neuron loss in a model of Parkinson’s disease.Layal MaatoukAnne-Claire CompagnionMaria-Angeles Carrillo-de SauvageAlexis-Pierre BemelmansSabrina Leclere-TurbantVincent CirotteauMira TohmeAllen BekeMichaël TrichetVirginie BazinBobby N. TrawickRichard M. RansohoffFrançois TroncheBénédicte ManourySheela VyasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Layal Maatouk Anne-Claire Compagnion Maria-Angeles Carrillo-de Sauvage Alexis-Pierre Bemelmans Sabrina Leclere-Turbant Vincent Cirotteau Mira Tohme Allen Beke Michaël Trichet Virginie Bazin Bobby N. Trawick Richard M. Ransohoff François Tronche Bénédicte Manoury Sheela Vyas TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
description	Inflammation is a component of Parkinson’s disease. Here the authors show that activation of Toll-like receptor 9 controlled by microglial glucocorticoid receptor signaling, contributes to dopamine neuron loss in a model of Parkinson’s disease.
format	article
author	Layal Maatouk Anne-Claire Compagnion Maria-Angeles Carrillo-de Sauvage Alexis-Pierre Bemelmans Sabrina Leclere-Turbant Vincent Cirotteau Mira Tohme Allen Beke Michaël Trichet Virginie Bazin Bobby N. Trawick Richard M. Ransohoff François Tronche Bénédicte Manoury Sheela Vyas
author_facet	Layal Maatouk Anne-Claire Compagnion Maria-Angeles Carrillo-de Sauvage Alexis-Pierre Bemelmans Sabrina Leclere-Turbant Vincent Cirotteau Mira Tohme Allen Beke Michaël Trichet Virginie Bazin Bobby N. Trawick Richard M. Ransohoff François Tronche Bénédicte Manoury Sheela Vyas
author_sort	Layal Maatouk
title	TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
title_short	TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
title_full	TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
title_fullStr	TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
title_full_unstemmed	TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
title_sort	tlr9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7e620af317d44ae895a31e6a05dc755b
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TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

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