Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer

Abstract Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. The combination of radio-colloids and dye method is the best method recognized. The reagents and equipment required in the process of the combined method are complex and expe...

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Autores principales:	Liang Li, Ning Gao, Ai Qing Yang, Wen Hao Xu, Yu Ding, Jun Chu, Xiao Na Lin, Jia Qi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e6414c4690a47f5bbe99138c9ecf369
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spelling	oai:doaj.org-article:7e6414c4690a47f5bbe99138c9ecf3692021-12-02T17:52:32ZApplication of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer10.1038/s41598-021-91641-12045-2322https://doaj.org/article/7e6414c4690a47f5bbe99138c9ecf3692021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91641-1https://doaj.org/toc/2045-2322Abstract Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. The combination of radio-colloids and dye method is the best method recognized. The reagents and equipment required in the process of the combined method are complex and expensive, so there are certain restrictions in the use of primary medical institutions. As a new tracer, fluorescent tracer technology has attracted much attention. We aimed to evaluate the feasibility and safety of fluorescein for SLNB in breast cancer. In this study, a total of 123 patients with breast cancer were divided into group A (n = 67) and group B (n = 56). The efficacy of Indocyanine green (ICG) combined with methylene blue (group A) and fluorescein combined with methylene blue (group B) in SLNB of breast cancer was compared, complications were observed at the same time. No local or systemic reactions were observed in the two groups. In group A, Sentinel lymph nodes of breast cancer were detected in 63 patients, with a detection rate of 94.0% (63/67), a false-negative rate of 7.5% (4/53). In group B, Sentinel lymph nodes of breast cancer were detected in 52 patients, with a detection rate of 92.9% (52/56), a false-negative rate of 7.5% (3/40). There was no significant difference in biopsy results between the two groups. This prospective clinical study suggests that SLNB using fluorescein and ultraviolet LED light is feasible in breast cancer patients. No adverse reactions were observed in this study, but larger studies are needed to properly assess the adverse reaction rate.Liang LiNing GaoAi Qing YangWen Hao XuYu DingJun ChuXiao Na LinJia Qi LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Li Ning Gao Ai Qing Yang Wen Hao Xu Yu Ding Jun Chu Xiao Na Lin Jia Qi Liu Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
description	Abstract Sentinel lymph node biopsy (SLNB) for axillary lymph node staging in early breast cancer has been widely recognized. The combination of radio-colloids and dye method is the best method recognized. The reagents and equipment required in the process of the combined method are complex and expensive, so there are certain restrictions in the use of primary medical institutions. As a new tracer, fluorescent tracer technology has attracted much attention. We aimed to evaluate the feasibility and safety of fluorescein for SLNB in breast cancer. In this study, a total of 123 patients with breast cancer were divided into group A (n = 67) and group B (n = 56). The efficacy of Indocyanine green (ICG) combined with methylene blue (group A) and fluorescein combined with methylene blue (group B) in SLNB of breast cancer was compared, complications were observed at the same time. No local or systemic reactions were observed in the two groups. In group A, Sentinel lymph nodes of breast cancer were detected in 63 patients, with a detection rate of 94.0% (63/67), a false-negative rate of 7.5% (4/53). In group B, Sentinel lymph nodes of breast cancer were detected in 52 patients, with a detection rate of 92.9% (52/56), a false-negative rate of 7.5% (3/40). There was no significant difference in biopsy results between the two groups. This prospective clinical study suggests that SLNB using fluorescein and ultraviolet LED light is feasible in breast cancer patients. No adverse reactions were observed in this study, but larger studies are needed to properly assess the adverse reaction rate.
format	article
author	Liang Li Ning Gao Ai Qing Yang Wen Hao Xu Yu Ding Jun Chu Xiao Na Lin Jia Qi Liu
author_facet	Liang Li Ning Gao Ai Qing Yang Wen Hao Xu Yu Ding Jun Chu Xiao Na Lin Jia Qi Liu
author_sort	Liang Li
title	Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
title_short	Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
title_full	Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
title_fullStr	Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
title_full_unstemmed	Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
title_sort	application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7e6414c4690a47f5bbe99138c9ecf369
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Application of fluorescein combined with methylene blue in sentinel lymph node biopsy of breast cancer

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