Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment

Epilepsy is one of the most common neurological disorders in humans and dogs. The structure and composition of gut microbiome associated to this disorder has not yet been analyzed in depth but there is evidence that suggests a possible influence of gut bacteria in controlling seizures. The aim of th...

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Autores principales:	Sylvia García-Belenguer, Laura Grasa, Olga Valero, Jorge Palacio, Isabel Luño, Belén Rosado
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microbiota epilepsy antiepileptic drugs dogs Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/7e662d34b26b4497aa77215b81f1af39
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spelling	oai:doaj.org-article:7e662d34b26b4497aa77215b81f1af392021-11-25T16:16:03ZGut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment10.3390/ani111131212076-2615https://doaj.org/article/7e662d34b26b4497aa77215b81f1af392021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3121https://doaj.org/toc/2076-2615Epilepsy is one of the most common neurological disorders in humans and dogs. The structure and composition of gut microbiome associated to this disorder has not yet been analyzed in depth but there is evidence that suggests a possible influence of gut bacteria in controlling seizures. The aim of this study was to investigate the changes in gut microbiota associated to canine idiopathic epilepsy (IE) and the possible influence of antiepileptic drugs (AEDs) on the modulation of this microbiota. Faecal microbiota composition was analyzed using sequencing of bacterial 16S rRNA gene in a group of healthy controls (<i>n</i> = 12) and a group of epileptic dogs both before (<i>n</i> = 10) and after a 30-day single treatment with phenobarbital or imepitoin (<i>n</i> = 9). Epileptic dogs showed significantly reduced abundance of GABA (<i>Pseudomonadales</i>, <i>Pseudomonadaceae, Pseudomonas</i> and <i>Pseudomona_graminis</i>) and SCFAs-producing bacteria (<i>Peptococcaceae, Ruminococcaceae</i> and <i>Anaerotruncus</i>) as well as bacteria associated with reduced risk for brain disease (<i>Prevotellaceae</i>) than control dogs. The administration of AEDs during 30 days did not modify the gut microbiota composition. These results are expected to contribute to the understanding of canine idiopathic epilepsy and open up the possibility of studying new therapeutic approaches for this disorder, including probiotic intervention to restore gut microbiota in epileptic individuals.Sylvia García-BelenguerLaura GrasaOlga ValeroJorge PalacioIsabel LuñoBelén RosadoMDPI AGarticlemicrobiotaepilepsyantiepileptic drugsdogsVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3121, p 3121 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiota epilepsy antiepileptic drugs dogs Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	microbiota epilepsy antiepileptic drugs dogs Veterinary medicine SF600-1100 Zoology QL1-991 Sylvia García-Belenguer Laura Grasa Olga Valero Jorge Palacio Isabel Luño Belén Rosado Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
description	Epilepsy is one of the most common neurological disorders in humans and dogs. The structure and composition of gut microbiome associated to this disorder has not yet been analyzed in depth but there is evidence that suggests a possible influence of gut bacteria in controlling seizures. The aim of this study was to investigate the changes in gut microbiota associated to canine idiopathic epilepsy (IE) and the possible influence of antiepileptic drugs (AEDs) on the modulation of this microbiota. Faecal microbiota composition was analyzed using sequencing of bacterial 16S rRNA gene in a group of healthy controls (<i>n</i> = 12) and a group of epileptic dogs both before (<i>n</i> = 10) and after a 30-day single treatment with phenobarbital or imepitoin (<i>n</i> = 9). Epileptic dogs showed significantly reduced abundance of GABA (<i>Pseudomonadales</i>, <i>Pseudomonadaceae, Pseudomonas</i> and <i>Pseudomona_graminis</i>) and SCFAs-producing bacteria (<i>Peptococcaceae, Ruminococcaceae</i> and <i>Anaerotruncus</i>) as well as bacteria associated with reduced risk for brain disease (<i>Prevotellaceae</i>) than control dogs. The administration of AEDs during 30 days did not modify the gut microbiota composition. These results are expected to contribute to the understanding of canine idiopathic epilepsy and open up the possibility of studying new therapeutic approaches for this disorder, including probiotic intervention to restore gut microbiota in epileptic individuals.
format	article
author	Sylvia García-Belenguer Laura Grasa Olga Valero Jorge Palacio Isabel Luño Belén Rosado
author_facet	Sylvia García-Belenguer Laura Grasa Olga Valero Jorge Palacio Isabel Luño Belén Rosado
author_sort	Sylvia García-Belenguer
title	Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
title_short	Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
title_full	Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
title_fullStr	Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
title_full_unstemmed	Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment
title_sort	gut microbiota in canine idiopathic epilepsy: effects of disease and treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e662d34b26b4497aa77215b81f1af39
work_keys_str_mv	AT sylviagarciabelenguer gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment AT lauragrasa gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment AT olgavalero gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment AT jorgepalacio gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment AT isabelluno gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment AT belenrosado gutmicrobiotaincanineidiopathicepilepsyeffectsofdiseaseandtreatment
_version_	1718413264979755008

Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment

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