Cellular census of human fibrosis defines functionally distinct stromal cell types and states

New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mesenchymal cells during pathogenic fibrogenesis.

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Autores principales:	Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e67ad4ab04e40f987c55274c1eafb3b
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spelling	oai:doaj.org-article:7e67ad4ab04e40f987c55274c1eafb3b2021-12-02T17:51:11ZCellular census of human fibrosis defines functionally distinct stromal cell types and states10.1038/s41467-020-16264-y2041-1723https://doaj.org/article/7e67ad4ab04e40f987c55274c1eafb3b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16264-yhttps://doaj.org/toc/2041-1723New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mesenchymal cells during pathogenic fibrogenesis.Thomas B. LaytonLynn WilliamsFiona McCannMingjun ZhangMarco FritzscheHuw Colin-YorkMarisa CabritaMichael T. H. NgMarc FeldmannStephen N. SansomDominic FurnissWeilin XieJagdeep NanchahalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas B. Layton Lynn Williams Fiona McCann Mingjun Zhang Marco Fritzsche Huw Colin-York Marisa Cabrita Michael T. H. Ng Marc Feldmann Stephen N. Sansom Dominic Furniss Weilin Xie Jagdeep Nanchahal Cellular census of human fibrosis defines functionally distinct stromal cell types and states
description	New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mesenchymal cells during pathogenic fibrogenesis.
format	article
author	Thomas B. Layton Lynn Williams Fiona McCann Mingjun Zhang Marco Fritzsche Huw Colin-York Marisa Cabrita Michael T. H. Ng Marc Feldmann Stephen N. Sansom Dominic Furniss Weilin Xie Jagdeep Nanchahal
author_facet	Thomas B. Layton Lynn Williams Fiona McCann Mingjun Zhang Marco Fritzsche Huw Colin-York Marisa Cabrita Michael T. H. Ng Marc Feldmann Stephen N. Sansom Dominic Furniss Weilin Xie Jagdeep Nanchahal
author_sort	Thomas B. Layton
title	Cellular census of human fibrosis defines functionally distinct stromal cell types and states
title_short	Cellular census of human fibrosis defines functionally distinct stromal cell types and states
title_full	Cellular census of human fibrosis defines functionally distinct stromal cell types and states
title_fullStr	Cellular census of human fibrosis defines functionally distinct stromal cell types and states
title_full_unstemmed	Cellular census of human fibrosis defines functionally distinct stromal cell types and states
title_sort	cellular census of human fibrosis defines functionally distinct stromal cell types and states
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7e67ad4ab04e40f987c55274c1eafb3b
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Cellular census of human fibrosis defines functionally distinct stromal cell types and states

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