Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures
Replication of bone marrow niches is essential for the evaluation of the toxicity and efficacy of multiple drug candidates and understanding of cell development. Recreation of the complex biological environment of bone marrow in a suitable format for such studies can be accomplished using bone-mimet...
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Taylor & Francis Group
2018
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oai:doaj.org-article:7e689e9f90dc4f6db598c7bcaf3383662021-12-02T12:03:57ZLayered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures2055-033210.1080/20550324.2018.1556895https://doaj.org/article/7e689e9f90dc4f6db598c7bcaf3383662018-10-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2018.1556895https://doaj.org/toc/2055-0332Replication of bone marrow niches is essential for the evaluation of the toxicity and efficacy of multiple drug candidates and understanding of cell development. Recreation of the complex biological environment of bone marrow in a suitable format for such studies can be accomplished using bone-mimetic constructs based on three-dimensional (3D) nanocomposite-coated cell scaffolds with inverted colloidal crystal geometry. Layer-by-layer (LBL) assembled nanocomposites combine the mechanical properties and surface topography of bone with the transparency of 3D cell matrices. Such rare combination of properties allows for discrimination and control of complex biological processes such as differentiation of bone marrow stromal cells. LBL biomimetic nanocomposites open the pathway toward better understanding of the interactions between stromal cells and the extracellular matrix in the bone marrow microenvironment, in order to achieve the accurate engineering of the bone marrow niches.Yichun WangEdward JanMeghan CuddihyJoong Hwan BahngNicholas KotovTaylor & Francis Grouparticlebiomimetic compositeslayer-by-layer assemblylbllblthree-dimensional cell culturesbone marrowtissue replicasdrug discoveryMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 4, Iss 4, Pp 156-166 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
biomimetic composites layer-by-layer assembly lbl lbl three-dimensional cell cultures bone marrow tissue replicas drug discovery Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 |
| spellingShingle |
biomimetic composites layer-by-layer assembly lbl lbl three-dimensional cell cultures bone marrow tissue replicas drug discovery Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Yichun Wang Edward Jan Meghan Cuddihy Joong Hwan Bahng Nicholas Kotov Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| description |
Replication of bone marrow niches is essential for the evaluation of the toxicity and efficacy of multiple drug candidates and understanding of cell development. Recreation of the complex biological environment of bone marrow in a suitable format for such studies can be accomplished using bone-mimetic constructs based on three-dimensional (3D) nanocomposite-coated cell scaffolds with inverted colloidal crystal geometry. Layer-by-layer (LBL) assembled nanocomposites combine the mechanical properties and surface topography of bone with the transparency of 3D cell matrices. Such rare combination of properties allows for discrimination and control of complex biological processes such as differentiation of bone marrow stromal cells. LBL biomimetic nanocomposites open the pathway toward better understanding of the interactions between stromal cells and the extracellular matrix in the bone marrow microenvironment, in order to achieve the accurate engineering of the bone marrow niches. |
| format |
article |
| author |
Yichun Wang Edward Jan Meghan Cuddihy Joong Hwan Bahng Nicholas Kotov |
| author_facet |
Yichun Wang Edward Jan Meghan Cuddihy Joong Hwan Bahng Nicholas Kotov |
| author_sort |
Yichun Wang |
| title |
Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| title_short |
Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| title_full |
Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| title_fullStr |
Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| title_full_unstemmed |
Layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| title_sort |
layered biomimetic nanocomposites replicate bone surface in three-dimensional cell cultures |
| publisher |
Taylor & Francis Group |
| publishDate |
2018 |
| url |
https://doaj.org/article/7e689e9f90dc4f6db598c7bcaf338366 |
| work_keys_str_mv |
AT yichunwang layeredbiomimeticnanocompositesreplicatebonesurfaceinthreedimensionalcellcultures AT edwardjan layeredbiomimeticnanocompositesreplicatebonesurfaceinthreedimensionalcellcultures AT meghancuddihy layeredbiomimeticnanocompositesreplicatebonesurfaceinthreedimensionalcellcultures AT joonghwanbahng layeredbiomimeticnanocompositesreplicatebonesurfaceinthreedimensionalcellcultures AT nicholaskotov layeredbiomimeticnanocompositesreplicatebonesurfaceinthreedimensionalcellcultures |
| _version_ |
1718394698573283328 |